Evidence map›Paper›PMID 42182844›Full record

ArticleOpen forum infectious diseases2026

Preexisting Humoral Immunity Against Seasonal Coronaviruses Enhances Antibody Responses on SARS-CoV-2 Vaccination.

Etsuro Nanishi, Matthew Hwang, Ana Citlali Márquez, Walter Byrne, Maria-Rosa La Neve, Alice Litosh, Jasmik S Saini, Kimberly Thompson, Nicole Wisener, Makiko Nanishi and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Open forum infectious diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Etsuro NanishiDivision of Infectious Diseases, Department of Paediatrics, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.ORCID https://orcid.org/0000-0002-9957-7162
Matthew HwangDivision of Infectious Diseases, Department of Paediatrics, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.ORCID https://orcid.org/0000-0002-1384-3723
Ana Citlali MárquezPublic Health Laboratory, British Columbia Centre for Disease Control, Vancouver, British Columbia, Canada.
Walter ByrneDivision of Infectious Diseases, Department of Paediatrics, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.
Maria-Rosa La NeveDivision of Infectious Diseases, Department of Paediatrics, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.
Alice LitoshDivision of Infectious Diseases, Department of Paediatrics, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.
Jasmik S SainiDivision of Infectious Diseases, Department of Paediatrics, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.
Kimberly ThompsonDivision of Infectious Diseases, Department of Paediatrics, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.
Nicole WisenerDivision of Infectious Diseases, Department of Paediatrics, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.
Makiko NanishiDivision of Respiratory Medicine, Department of Paediatrics, The Hospital for Sick Children, Toronto, Ontario, Canada.
Julia E M UptonDivision of Immunology and Allergy, Department of Paediatrics, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.
Aaron CampigottoDivision of Microbiology, Department of Paediatric Laboratory Medicine, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.
Michelle BartonDivision of Infectious Diseases, Department of Paediatrics, Children's Hospital, London Health Sciences Centre, University of Western Ontario, London, Ontario, Canada.ORCID https://orcid.org/0000-0003-1760-6650
Agatha N JassemPublic Health Laboratory, British Columbia Centre for Disease Control, Vancouver, British Columbia, Canada.
Upton D AllenDivision of Infectious Diseases, Department of Paediatrics, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.ORCID https://orcid.org/0000-0002-2326-7731

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: High homology and cross-reactive immune responses have been reported between SARS-CoV-2 and seasonal human coronaviruses (HCoVs). However, the impact of preexisting immunity against seasonal HCoVs on SARS-CoV-2 vaccination is undetermined. Methods: We conducted a cross-sectional study involving pediatric and adult participants between August 2020 and August 2023. IgG titers against SARS-CoV-2 and seasonal HCoV-229E, -HKU1, -NL63, and -OC43 were quantified by electrochemiluminescent immunoassay. A paired analysis was performed in a subset of participants with samples collected before and after SARS-CoV-2 vaccination. Results: A total of 1804 participants were enrolled (median age, 44 years; range, 2-95). IgG titers against HCoV-229E, -HKU1, and -OC43 increased during early childhood. Among participants without prior SARS-CoV-2 infection who were SARS-CoV-2-vaccinated, anti-spike IgG titers against SARS-CoV-2 positively correlated with titers against HCoV-OC43, -HKU1, and -NL63 (Spearman Conclusions: Higher baseline immunity to HCoV-HKU1 and -OC43 was associated with stronger SARS-CoV-2 vaccine-induced antibody responses. These findings suggest that preexisting immunity against seasonal betacoronaviruses may enhance humoral immune response to SARS-CoV-2 vaccination.

Indexed as

betacoronavirusespreexisting immunitySARS-CoV-2seasonal coronavirusesvaccine

Identifiers

PMID42182844
PMCPMC13196868

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.