Evidence map›Paper›PMID 42182840›Full record

ArticleOpen forum infectious diseases2026

Impact of Extended Criteria Donor Transplants on Infections in Kidney and Liver Transplant Recipients and Marginal Donor Definition Criteria: A Systematic Review.

Cecilia Bonazzetti, Milo Gatti, Maria Clara Chionsini, Chiara Calgarini, Martina Casarini, Luca Ceccarelli, Matteo Rinaldi, Giorgia Comai, Maria Cristina Morelli, Cristiana Laici and 5 more

Abstract read
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In one paragraph

Article in Open forum infectious diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Cecilia BonazzettiDepartment of Medical and Surgical Sciences, Alma Mater Studiorum, University of Bologna, Bologna, Italy.ORCID https://orcid.org/0000-0002-5661-1324
Milo GattiDepartment of Medical and Surgical Sciences, Alma Mater Studiorum, University of Bologna, Bologna, Italy.ORCID https://orcid.org/0000-0003-3018-3779
Maria Clara ChionsiniDepartment of Medical and Surgical Sciences, Alma Mater Studiorum, University of Bologna, Bologna, Italy.
Chiara CalgariniDepartment of Medical and Surgical Sciences, Alma Mater Studiorum, University of Bologna, Bologna, Italy.ORCID https://orcid.org/0009-0002-7300-3918
Martina CasariniDepartment of Medical and Surgical Sciences, Alma Mater Studiorum, University of Bologna, Bologna, Italy.
Luca CeccarelliDepartment of Medical and Surgical Sciences, Alma Mater Studiorum, University of Bologna, Bologna, Italy.ORCID https://orcid.org/0000-0001-6448-5607
Matteo RinaldiDepartment of Medical and Surgical Sciences, Alma Mater Studiorum, University of Bologna, Bologna, Italy.ORCID https://orcid.org/0000-0002-3568-5973
Giorgia ComaiNephrology, Dialysis and Renal Transplant Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy.
Maria Cristina MorelliInternal Medicine Unit for the Treatment of Severe Organ Failure, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy.
Cristiana LaiciDivision of Anesthesiology, Department of Anesthesia and Intensive Care, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy.
Antonio SiniscalchiDivision of Anesthesiology, Department of Anesthesia and Intensive Care, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy.
Matteo RavaioliDepartment of Medical and Surgical Sciences, Alma Mater Studiorum, University of Bologna, Bologna, Italy.
Nicola AlvaroRegional Transplant Department, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy.
Pierluigi VialeDepartment of Medical and Surgical Sciences, Alma Mater Studiorum, University of Bologna, Bologna, Italy.
Maddalena GiannellaDepartment of Medical and Surgical Sciences, Alma Mater Studiorum, University of Bologna, Bologna, Italy.ORCID https://orcid.org/0000-0001-8273-7601

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Extended criteria donors (ECDs) have become an important source of organs, but their association with infection risk remains unclear. This systematic review assessed the impact of ECD versus standard criteria donors (SCDs) on infection rates in kidney and liver transplant recipients and analyzed the variability of ECD definitions. Methods: Three different literature databases were searched up to June 2024 for randomized controlled trials or observational studies comparing infection rates between ECD and SCD recipients. Studies without quantitative data or comparator groups were excluded. Outcomes were measured at 30-180 days and 1, 3, and 5 years posttransplant, evaluating both bacterial and viral infections. Results: A total of 11 119 articles were screened and 131 studies included. At 30 days, bacterial infections occurred at similar rates between ECD and SCD recipients (odds ratio [OR] 1.15, 95% confidence interval [CI] .86-1.53, Conclusions: Current evidence does not definitively establish a link between ECD and infection risk, highlighting the need for standardized donor definitions and routine reporting of infections as ECD outcomes.

Indexed as

expanded criteria donorextended criteria donorkidney transplantationliver transplantationmarginal donor

Identifiers

PMID42182840
PMCPMC13196869

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.