ArticleFrontiers in behavioral neuroscience2026
Sex-specific hippocampal microstructural alterations in 11-12-year-old adolescents with a history of mild traumatic brain injury.
Article in Frontiers in behavioral neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: Mild traumatic brain injury (mTBI) is common in children and adolescents and frequently accompanied by transient cognitive and emotional disturbances. While pediatric mTBI can shape subsequent brain maturation, its impact on neurodevelopmental trajectories remains poorly understood, particularly regarding hippocampal microstructure, a region critical for memory and highly vulnerable to brain injury. Methods: Using restriction spectrum imaging (RSI) data from the Adolescent Brain Cognitive Development Study (ABCD Study Results: Male adolescents with a history of mTBI exhibited higher hippocampal restricted normalized diffusion (RND) than their peers without mTBI (Bonferroni-corrected Discussion: These findings demonstrate sex-specific hippocampal microstructural alterations in young adolescents with a history of mTBI, highlighting potential neuroplastic adaptations during development. Although causal inference is limited given the cross-sectional design of the analysis, and mTBI history was based on retrospective parent report, the results underscore the importance of considering sex differences in recovery mechanisms and may inform future efforts to identify neuroimaging biomarkers that predict recovery trajectories and guide targeted interventions.
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