ArticleJournal of thoracic disease2026
Association between the endothelial activation and stress index and 30-day in-hospital mortality rate in patients with traumatic lung injury: a retrospective analysis based on the MIMIC-IV database.
Article in Journal of thoracic disease, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: The endothelial activation and stress index (EASIX) quantifies endothelial injury and serves as a validated surrogate marker for endothelial damage. Individuals with traumatic lung injury (TLI) in the intensive care unit (ICU) often exhibit endothelial impairment. However, the prognostic implication of EASIX in this population remains unclear. Therefore, this study aims to investigate the relationship between EASIX and prognosis in patients with TLI. Methods: Clinical data of individuals with TLI in the ICU were extracted from the Medical Information Mart for Intensive Care (MIMIC)-IV-3.1 database. The EASIX was calculated as lactate dehydrogenase (LDH) (U/L) × creatinine (mg/dL) / platelet count (PLT) (10 Results: The analysis encompassed 231 participants. After full adjustment for confounding variables, Cox regression revealed a significant correlation between elevated levels of EASIX and an increased risk of IHM [hazard ratio (HR) =2.895, 95% confidence interval (CI): 1.245-6.735]. RCS analysis demonstrated an approximately linear relationship between EASIX and mortality (P>0.05 for nonlinearity). The AUC of EASIX alone for predicting IHM was 0.709 (95% CI: 0.621-0.797) in the overall cohort. A RF model incorporating EASIX achieved AUC values of 0.973 and 0.753 in the training and validation sets, respectively, indicating robust predictive performance. Conclusions: EASIX is a reliable prognostic indicator for individuals with TLI. Larger prospective investigations are required to confirm causality.
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