ArticleJournal of thoracic disease2026
Dual-energy computed tomography venography parameters as potential indicators for pulmonary embolism in deep vein thrombosis.
Article in Journal of thoracic disease, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: The nonspecific nature of pulmonary embolism (PE) in patients initially diagnosed as symptomatic deep vein thrombosis (DVT) often leads to instances of underdiagnosis. The thrombus density of the DVT could serve as a predictive factor for PE. Dual-energy (DE) computed tomography (CT) obtains extra attenuation measurements to differentiate thrombus composition. Therefore, this retrospective study aimed to investigate whether DE-CT venography (DE-CTV) parameters of the DVT could predict the asymptomatic PE occurrence in a single tertiary institution in China. Methods: Between March 2020 and October 2023, patients with DVT diagnosed through DE-CTV were retrospectively identified. Thrombus density ratio, normalized iodine concentration (NIC, %), normalized effective atomic number (NZ Results: Finally, a total of 49 patients were included in this study, including 24 patients in the DVT-only group and 25 patients in the DVT-PE group. Thrombus density ratio, NIC, NZ Conclusions: The NIC derived from DE-CTV is independently associated with asymptomatic synchronous PE in patients with lower-extremity DVT. The proposed NIC cutoff value is exploratory and requires further validation.
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