ArticleJournal of thoracic disease2026
Early surgery before the onset of symptoms: a retrospective analysis of congenital cystic adenomatoid malformations of the lung.
Article in Journal of thoracic disease, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: There is currently controversy regarding whether prophylactic surgery is necessary for asymptomatic patients with congenital pulmonary cystic adenomatoid malformation (CCAM). This study analyzed the clinical characteristics of congenital cystic adenomatoid malformation of the lungs, as well as the outcomes and timing of surgical intervention. Methods: Clinical data of children at the Children's Hospital of Fudan University from March 2016 to March 2024 having pathologically confirmed congenital cystic adenomatoid malformation of the lungs were screened to analyze the characteristics of their pathogenesis and the current status of their diagnosis and treatment. Data were analyzed using the Chi-squared test and Mann-Whitney test. Results: A total of 148 children with CCAM were included. Sixty-six patients (44.6%) had presented with respiratory symptoms. The patients in the symptomatic group had a significantly lower mean age at the time of operation (11 Conclusions: The short-term postoperative course was shorter in the asymptomatic group, and surgical treatment before the onset of symptoms may offer a better immediate outcome. We suggest that prophylactic lobectomy should be performed as early as possible.
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