ArticleJournal of thoracic disease2026
Rapid decline in lung function is associated with more chronic respiratory symptoms, more severe small airway dysfunction and lung structural changes.
Article in Journal of thoracic disease, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Accelerated lung function decline is an important factor affecting the development and prognosis of chronic obstructive pulmonary disease (COPD), but its clinical characteristics have not been determined. We conduct a retrospective study to assess the clinical characteristics of participants with accelerated lung function decline. Methods: This study was based on the participants of Early Chronic Obstructive Pulmonary Disease (ECOPD) study enrolled in 2019-2020. Participants completed demographic data collection, COPD risk factor questionnaire, chronic respiratory symptom assessment, spirometry, impulse oscillometry (IOS) and computed tomography (CT) scan. We retrospectively sought lung function results from some of those who participated in the COPD epidemiology survey in 2012-2013 to obtain the rate of decline in lung function. Then we calculated the annual rate of decline based on the difference in lung function between 2012-2013 and 2019-2020. Accelerated lung function decline was defined as an annual decline in forced expiratory volume in one second (FEV Results: Among 298 participants with spirometry results in 2012-2013, 67 (22.5%) had an accelerated decline in pre-bronchodilator FEV Conclusions: Participants with an accelerated decline in lung function had more severe chronic respiratory symptoms, structural lung changes, and SAD.
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