Glutamate-cysteine ligase catalytic related glutathione metabolism inhibited high mobility group box 1 release by regulating epithelium ferroptosis in asthma.

Haiqin Liu, Caiming Zhong, Xuran Jiang, Yuan Yuan, Jianing Zhang, Hao Tang

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Article in Journal of thoracic disease, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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6 authors.

Haiqin Liu *Department of Respiratory and Critical Care Medicine, Shanghai Changzheng Hospital, Naval Medical University, Shanghai, China.

Caiming Zhong *Department of Respiratory and Critical Care Medicine, Shanghai Changzheng Hospital, Naval Medical University, Shanghai, China.

Xuran Jiang *Department of Respiratory and Critical Care Medicine, Shanghai Changzheng Hospital, Naval Medical University, Shanghai, China.

Yuan YuanDepartment of Respiratory and Critical Care Medicine, Shanghai Changzheng Hospital, Naval Medical University, Shanghai, China.

Jianing ZhangDepartment of Respiratory and Critical Care Medicine, Shanghai Changzheng Hospital, Naval Medical University, Shanghai, China.

Hao TangDepartment of Respiratory and Critical Care Medicine, Shanghai Changzheng Hospital, Naval Medical University, Shanghai, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Previous research indicated that asthma patients were with abnormal glutathione (GSH) metabolism. However, the role of glutamate-cysteine ligase catalytic (GCLC), as the key enzyme for GSH synthesis, remains ambiguous in asthma pathogenesis. Our study aimed to elucidate the role of GSH metabolism and Methods: We collected serum from healthy controls, asthma patients, and asthma bagg albino/c (BALB/c) mouse induced by house dust mite (HDM) to analyze GSH/oxidized GSH (GSSG) ratio. Results: We found that GSH/GSSG ratio decreased in asthma patients and mice. Additionally, inhibition of GCLC aggregated airway inflammation and remodeling in asthma by mediating GSH metabolism. Furthermore, fat mass and obesity-associated protein (FTO) regulated N6-methyladenosine (m6A) demethylation of Conclusions: In asthma, GSH metabolism is abnormal and

Indexed as

Asthmaferroptosisglutamate-cysteine ligase catalytic (GCLC)glutathione (GSH)high mobility group box 1 (HMGB1)

Identifiers

PMID42182742

DOI10.21037/jtd-2026-1-0009

PMCPMC13190003

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LicenceCC BY-NC-ND

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.