ReviewJournal of thoracic disease2026
Narrative review of fluid dynamics in the left ventricle: from the perspective of aortic regurgitation.
Review in Journal of thoracic disease, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Authors and funding
11 authors.
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Abstract
Background and Objective: From a fluid dynamics perspective, understanding intraventricular blood flow is essential for clarifying the mechanisms, progression, and potential therapeutic targets of various cardiac diseases. Recent advancements in imaging techniques have enabled the visualization of left ventricle (LV) blood flow, particularly the vortex formed during diastole. However, the inherently complex and dynamic nature of LV fluid motion makes the quantitative assessment of vortex function highly challenging. The impact of aortic regurgitation (AR) on LV fluid dynamics is equally critical for understanding the progression of cardiac dysfunction, yet its exact influence remains largely unclear. This manuscript is a narrative review of this novel perspective of AR in the context of fluid dynamics. Methods: Articles from PubMed database and Google Scholar regarding LV blood flow and vortex assessment were reviewed. For the initial research, articles between 2010 and 2025 were prioritized, including original articles, case reports, and reviews. Following the initial search, additional articles were considered based on manual searches of references from the retrieved literature. Key Content and Findings: AR jets have several interactions with LV blood flow depending on its direction, and the eccentric jet can be oriented in several directions based on the relationship to the mitral inflow location. Conclusions: Various orientations of eccentric AR jet are possible and LV blood flow trajectory is modulated by the direction of AR jets. A reproducible classification of AR jet direction, combined with the quantification of vortex alterations according to jet direction, represents a vital step in elucidating the specific roles of these vortices in cardiac function.
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