ArticleJournal of thoracic disease2026
Short-term gaseous and particulate air pollution exposure and risk of acute kidney injury: a 12-year case-crossover study [2013-2024] in Guangzhou, China.
Article in Journal of thoracic disease, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Acute kidney injury (AKI) is a major public health burden associated with high morbidity, significantly increasing long-term mortality, and escalating healthcare costs. While long-term air pollution exposure is a known risk factor for chronic kidney disease (CKD), evidence regarding the acute triggers of AKI remains limited, especially in Asian megacities with complex pollution profiles. We investigated the independent effects of major air pollutants on the risk of AKI using algorithmically identified clinical data. Methods: A time-stratified case-crossover study was conducted involving adults in Guangzhou, China [2013-2024]. We included patients with longitudinal serum creatinine records and strictly excluded those with end-stage renal disease (ESRD) or a history of kidney transplantation. AKI events were defined using the Kidney Disease: Improving Global Outcomes (KDIGO) serum creatinine criteria. Daily meteorological and air pollutant data were collected from respective monitoring stations. Conditional logistic regression and generalized additive models were employed to estimate the associations between short-term exposure to fine particulate matter [particulate matter less than 2.5 μm (PM Results: A total of 10,857 AKI cases (60.0% male; 62.2% aged <65 years) were included. In multi-pollutant models, gaseous pollutants showed robust independent associations with AKI. A 10 µg/m Conclusions: Short-term exposure to ambient SO
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