ArticleJournal of thoracic disease2026
Chemotherapy-free anlotinib-based regimens in advanced non-small cell lung cancer: a real-world retrospective cohort study.
Article in Journal of thoracic disease, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Anlotinib is established as a standard later-line treatment for advanced non-small cell lung cancer (NSCLC). However, the real-world efficacy of anlotinib-based chemotherapy-free combinations-particularly in earlier lines of therapy-remains insufficiently characterized. This study aimed to evaluate the survival outcomes of anlotinib monotherapy versus combination regimens and assess the impact of treatment line on efficacy. Methods: In this single-center, real-world retrospective cohort study, we analyzed 170 patients with advanced NSCLC. Patients were stratified into three cohorts: anlotinib monotherapy (Group A, n=62), anlotinib plus immunotherapy (Group A+I, n=57), and anlotinib plus targeted therapy (Group A+T, n=51). The primary endpoints were progression-free survival (PFS) and overall survival (OS), analyzed using Kaplan-Meier methods and Cox proportional hazards models. Results: The median PFS and OS for the entire cohort were 10 and 18.5 months, respectively. The objective response rate (ORR) and disease control rate (DCR) for the entire population were 17.6% and 84.8%, respectively. In the subgroups, the ORR was 18.8% (A+I) and 23.1% (A+T) Conclusions: Anlotinib-based, chemotherapy-free regimens demonstrate significantly greater efficacy than anlotinib monotherapy in advanced NSCLC. Furthermore, the upstream application of these regimens in earlier treatment lines is associated with markedly prolonged survival. These findings support anlotinib-based combinations as a promising chemotherapy-sparing strategy, particularly for patients unsuitable for or refusing chemotherapy.
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