ArticleJournal of thoracic disease2026
Relationship between systemic immune-inflammation index and risk of mortality among pneumonia patients: a systematic review with meta-analysis.
Article in Journal of thoracic disease, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: The association of systemic immune-inflammation index (SII) with mortality risk in patients with pneumonia remains unclear now. This meta-analysis aimed to identify the relationship between SII and risk of mortality among pneumonia patients. Methods: Several databases were searched up to September 10, 2025. Odds ratios (ORs) and 95% confidence intervals (CIs) were combined and subgroup analyses by the study design (single-center Results: Eleven studies with 2,841 cases were included with the mortality rate of 21.1%. Pooled results demonstrated that elevated SII was related to increased risk of mortality (OR =1.02, 95% CI: 1.00-1.05, P<0.001). Then subgroup analysis by the location of occurrence and etiology showed that the association between SII and risk of mortality was more significant among patients with CAP and bacterial pneumonia. Besides, subgroup analyses by the study design, severity of pneumonia, patient care setting, grouping method by SII and follow-up period further identified the association of SII with risk of mortality in pneumonia patients. Conclusions: SII might serve as a prognostic indicator in pneumonia and patients with elevated SII are faced with increased risk of mortality.
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