ArticleJournal of thoracic disease2026
Honeycomb wall thickening during acute deterioration of idiopathic pulmonary fibrosis: clinical, imaging and prognostic characteristics.
Article in Journal of thoracic disease, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: High-resolution computed tomography (HRCT) extent and patterns predict survival in acute exacerbation of idiopathic pulmonary fibrosis (AE-IPF). While established patterns including peripheral, multifocal and diffuse patterns associate with distinct prognostic outcomes, with the diffuse subtype having the poorest prognosis. We identified a novel imaging phenotype characterized by isolated honeycomb wall thickening on HRCT in IPF patients presenting with acute respiratory deterioration within 30 days. This pattern does not demonstrate new bilateral ground-glass opacities or consolidations required by prevailing American Thoracic Society (ATS) diagnostic criteria. Methods: This retrospective observational study enrolled patients with IPF treated at West China Hospital for acute deterioration between April 2012 and February 2023. A total of 142 patients with IPF at acute deterioration were collected and divided into two groups based on the newly appeared parenchymal abnormalities: 129 patients with AE-IPF [comprising peripheral (n=38), multifocal (n=75) and diffuse (n=16) patterns] and 13 patients with the honeycomb wall thickening pattern. We compared their clinical characteristics, treatment response and survival. Results: Patients with the honeycomb wall thickening pattern showed significant resolution of honeycomb wall on HRCT and improved partial pressure of arterial oxygen/fraction of inspired oxygen (PaO Conclusions: This study demonstrates that honeycomb wall thickening may represent a distinct and clinically significant HRCT of IPF patient at acute deterioration. Patients with this novel pattern respond to antimicrobial and corticosteroid therapy. These observations highlight the potential importance of recognizing this pattern in clinical practice to guide timely intervention and improve outcomes in IPF patients at acute deterioration.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.