ArticleJournal of thoracic disease2026
Improving self-care behaviors in patients with chronic obstructive pulmonary disease using a knowledge-based intelligent self-care system: protocol for a randomized controlled trial.
Article in Journal of thoracic disease, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
10 authors.
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Abstract
Background: Chronic obstructive pulmonary disease (COPD) imposes a substantial public health burden worldwide. Current COPD self-care management is largely nurse-led and often limited in accessibility and scalability. Artificial intelligence (AI) offers new opportunities to deliver personalized and scalable self-care support, yet evidence of its effectiveness remains limited. This randomized controlled trial (RCT) aims to evaluate an intelligent self-care platform designed to improve self-care behaviors in patients with COPD. Methods: A total of 104 patients diagnosed with COPD will be recruited and randomly assigned (1:1) to either the intervention group (n=52) or the control group (n=52). Participants in the intervention group will receive access to a 24/7 AI-enabled intelligent self-care platform for 3 months, while those in the control group will receive standard care. Participants will be encouraged to use the platform daily, and system logs will automatically record usage to monitor adherence. The primary outcomes will include the Chinese version of the Self-Care in COPD Inventory (SC-COPDI-C) and the Chinese version of the Self-Care Self-Efficacy Scale (SCSES-C). Data will be collected at baseline, 1 month, and 3 months. Outcome assessors will remain blinded to group allocation. Safety monitoring will include surveillance of adverse events and periodic review of AI-generated responses to identify potential medical inaccuracies. Generalized estimating equations (GEE) will be used to evaluate improvements in self-care behaviors. Discussion: This trial will evaluate the effectiveness of an AI-enabled intelligent self-care platform designed to enhance self-care behaviors and self-efficacy in patients with COPD. By integrating large language models (LLMs), retrieval-augmented generation (RAG), and a structured clinical knowledge base, the platform aims to provide personalized and evidence-based support for COPD self-management. The findings will provide important evidence regarding the feasibility, safety, and clinical impact of AI-driven self-care interventions and may inform the development of scalable digital health strategies for chronic disease management. Trial registration: The study protocol was registered on Chinese Clinical Trial Registry (ChiCTR2600123383).
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