Evidence map›Paper›PMID 42182618›Full record

ArticleDose-response : a publication of International Hormesis Society

The Effects of Tibetan Medicine Renqing Changjue Extracts on Cyclophosphamide-Induced Immunosuppression in a Mouse Model.

Zhao Jiang, Xiumei Kong, Xiaoying Zhang, Yaxin Lv, Siqi Wu, Xu Ji, Qin Zhao

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Article in Dose-response : a publication of International Hormesis Society. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Zhao JiangJoint Laboratory for the Study of Active Ingredients and Pharmacological Mechanisms of Tibetan Medicine at the Tibet Tibetan Medical Research Center, Xizang Minzu University, Xianyang, China.
Xiumei KongJoint Laboratory for the Study of Active Ingredients and Pharmacological Mechanisms of Tibetan Medicine at the Tibet Tibetan Medical Research Center, Xizang Minzu University, Xianyang, China.
Xiaoying ZhangJoint Laboratory for the Study of Active Ingredients and Pharmacological Mechanisms of Tibetan Medicine at the Tibet Tibetan Medical Research Center, Xizang Minzu University, Xianyang, China.
Yaxin LvJoint Laboratory for the Study of Active Ingredients and Pharmacological Mechanisms of Tibetan Medicine at the Tibet Tibetan Medical Research Center, Xizang Minzu University, Xianyang, China.
Siqi WuJoint Laboratory for the Study of Active Ingredients and Pharmacological Mechanisms of Tibetan Medicine at the Tibet Tibetan Medical Research Center, Xizang Minzu University, Xianyang, China.
Xu JiJoint Laboratory for the Study of Active Ingredients and Pharmacological Mechanisms of Tibetan Medicine at the Tibet Tibetan Medical Research Center, Xizang Minzu University, Xianyang, China.
Qin ZhaoJoint Laboratory for the Study of Active Ingredients and Pharmacological Mechanisms of Tibetan Medicine at the Tibet Tibetan Medical Research Center, Xizang Minzu University, Xianyang, China.ORCID https://orcid.org/0000-0003-4956-2541

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objectives: Renqing Changjue (RQCJ) is a form of Tibetan medicine recognized for its immunomodulatory effects. However, the underlying mechanisms through which it exerts these effects remain to be elucidated. Methods: We randomly divided 180 male Kunming mice into five groups: control, model (CTX), and high-, medium-, low-dose RQCJ (RQCJH, RQCJM, and RQCJL respectively). The mice received appropriate medications for 15 days. We measured body weight, thymus, spleen index, immune-related cytokines, T cells, and antibodies to evaluate the immunomodulatory effects. Finally, the impact of RQCJ on immunocompromised mice was examined using spleen transcriptome sequencing analysis. Results: The RQCJ can significantly enhance immune function by regulating specific and non-specific immunity. Transcriptome analysis revealed significant changes in the cytosolic DNA-sensing pathway, TNF signaling pathway, ECM-receptor interactions, and Chagas disease within the RQCJH group. The Jag1 and Tgtp1 genes showed significant upregulation and demonstrated noteworthy correlations with the proportions of T-cell subsets and levels of cytokine expression. Additionally, these genes, along with Rtp4, Irf7, Dhx58, Il1b, Ifi44, and Ifi35 may be the important gene targets for the action of RQCJ. Conclusion: This study provides new insights into the mechanisms by which RQCJ modulates immune responses, offering theoretical foundations for tumor treatment and clinical application.

Indexed as

cellular immunityhumoral immunitynonspecific immunityRQCJspleen transcriptome

Identifiers

PMID42182618
PMCPMC13195208

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