Evidence map›Paper›PMID 42182593›Full record

ArticleACG case reports journal2026

Organ Preservation After Total Neoadjuvant Therapy in a Patient With Low Rectal Adenocarcinoma and Crohn's Disease.

Russell Leong, Rachel Goodwin, Husein Moloo, Wael Shabana, Gordon Locke

Abstract readCase Reports
In one paragraph

Article in ACG case reports journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Russell LeongFaculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada.ORCID https://orcid.org/0000-0002-5030-7487
Rachel GoodwinThe Ottawa Hospital Cancer Centre, Ottawa, Ontario, Canada.
Husein MolooDivision of General Surgery, University of Ottawa, Ottawa, Ontario, Canada.
Wael ShabanaDivision of Radiology, University of Ottawa, Ottawa, Ontario, Canada.
Gordon LockeThe Ottawa Hospital Cancer Centre, Ottawa, Ontario, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Inflammatory bowel disease (IBD) is a relative contraindication to radiation. This case report describes a 53-year-old man with colorectal adenocarcinoma and a history of Crohn's disease who was treated under the organ preservation for rectal adenocarcinoma protocol to avoid total mesorectal excision. Over 30 months of follow-up, the patient continues to tolerate chemoradiotherapy and consolidation chemotherapy with manageable toxicity and achieved a sustained complete clinical response. This case supports emerging evidence that radiation may be feasible in select patients with IBD and highlights the potential role of non-surgical organ preservation strategies in colorectal cancer, even in the context of underlying IBD.

Indexed as

Crohn's diseaseinflammatory bowel diseaseorgan preservationradiationrectal cancer

Identifiers

PMID42182593
PMCPMC13197017

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.