ReviewCell insight2026
Challenges and opportunities: CAR-T cell therapy in autoimmune diseases.
Review in Cell insight, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Advances in targeted and cellular therapies for relapsed/refractory mantle cell lymphoma: immunotherapeutic strategies and challenges.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chimeric antigen receptor T (CAR-T) cell therapy is rapidly moving from hematologic malignancies into severe autoimmune disease, particularly B cell-mediated disorders such as systemic lupus erythematosus (SLE), systemic sclerosis (SSc) and inflammatory myopathies. Recent autologous and allogeneic studies show that deep immune-cell depletion can induce drug-free remission or major clinical responses in the refractory patients. However, translating CAR-T cell therapy into autoimmune disease raises challenges that differ from oncology, including target selection in heterogeneous immune ecosystems, depletion of nonpathogenic immune compartments, control of cytokine release syndrome and infection risk, definition of the optimal degree of CAR persistence, and scalable manufacturing. In this review, we summarize the major obstacles and emerging opportunities for CAR-T cell therapy in autoimmune diseases, with emphasis on representative clinical studies, candidate targets beyond CD19, engineering strategies to improve safety and durability, and the specific promise and limitations of allogeneic platforms.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.