Trial reportDrug design, development and therapy2026
Effects of Remimazolam Dose and Bolus Injection Rate on Hiccups During Painless Colonoscopy: A Double-Blind Randomized Clinical Trial.
Trial report in Drug design, development and therapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- The Effects of Low-Dose Remimazolam Adjunct on Propofol-Remifentanil Anaesthesia in Day Case Gynaecological Surgery: A Retrospective Cohort Study.Medicina (Kaunas, Lithuania) · 2026Observational
- Effects of Remimazolam Dose and Bolus Injection Rate on Hiccups During Painless Colonoscopy: A Double-Blind Randomized Clinical Trial [Letter].Drug design, development and therapy · 2026Article
- Effects of Remimazolam Dose and Bolus Injection Rate on Hiccups During Painless Colonoscopy: A Double-Blind Randomized Clinical Trial [Response to Letter].Drug design, development and therapy · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Remimazolam is increasingly used for procedural sedation because of its rapid onset, rapid recovery and favourable haemodynamic profile. However, hiccups remain a clinically relevant adverse event that may interfere with endoscopic manipulation. The independent and combined effects of remimazolam dose and injection rate on hiccup occurrence have not been well characterized. Methods: In this prospective, randomized, double-blind, 2×2 factorial trial, adult patients undergoing painless colonoscopy were randomized to receive remimazolam at 0.3 or 0.4 mg kg Results: Both the higher remimazolam dose (0.4 mg kg Conclusion: Both a higher remimazolam dose and a slower bolus injection rate were independently associated with a lower incidence of hiccups during painless colonoscopy. Remimazolam 0.4 mg kg
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