ReviewDrug design, development and therapy2026
Protection of Hygroscopic Pharmaceutical and Nutraceutical Active Ingredients via Film Coating Technologies: A Review.
Review in Drug design, development and therapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Biomimetic Coacervate Coatings: From Phase Separation Fundamentals to Advanced Biomedical Applications.Biomimetics (Basel, Switzerland) · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hygroscopicity poses a significant challenge in the formulation of pharmaceutical and nutraceutical products, as moisture absorption often leads to chemical degradation, physical instability, and compromised therapeutic efficacy. This narrative literature review, evaluated the comparative effectiveness of various polymeric systems and coating technologies as moisture barriers across diverse dosage forms, including tablets, powders, granules, and particulates. We analyzed a spectrum of barrier materials, including cellulose derivatives, polyvinylpyrrolidone, polyvinyl alcohol (PVA), methacrylates, and shellac, contrasting conventional solvent based techniques (fluid bed, spray drying, freeze drying coating) with advanced methodologies (hot melt coating, electrostatic dry coating, and Atomic Layer Deposition/ALD). Conventional coating systems utilizing HPMC and PVA were found to maintain moisture uptake below 1.5% during long-term storage (40°C/75% RH). However, more advanced strategies demonstrated superior protective capabilities, for instance, hotmelt coating employing lipid-based excipients (Precirol ATO 5) reduced moisture absorption by up to 85% at 75% RH. Furthermore, electrostatic dry coating showed a significant reduction in weight gain, decreasing from 6.5% to 3.3% compared to uncoated cores over a 48-hour period. Notably, ALD provided the most robust protection, preserving the amorphous stability of sensitive particles for up to two years under extreme conditions. This review highlights that film coatings not only mitigate moisture induced degradation but also enhance shelf life and improve the mechanical properties of dosage forms. These results underscore the versatility of coating technologies, enabling formulators to tailor strategies for highly moisture sensitive compounds.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.