Evidence map›Paper›PMID 42182563›Full record

ArticleFrontiers in aging neuroscience2026

Investigating hepatitis E virus seroprevalence in patients with Alzheimer's disease.

Tiberiu Daniel Capraru, Tim Christopher Bauer, Paula Jordan, Niklas M Weidner, Melisa Oensal, Lutz Froelich, Claudia Beisel, Lucrezia Hausner, Viet Loan Dao Thi

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In one paragraph

Article in Frontiers in aging neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Tiberiu Daniel CapraruChica and Heinz Schaller Research Group, Center of Infectious Diseases, Virology, Heidelberg University Hospital, Heidelberg, Germany.
Tim Christopher BauerDepartment of Clinical Infectious Diseases, Tropical Medicine, Heidelberg, Germany.
Paula JordanChica and Heinz Schaller Research Group, Center of Infectious Diseases, Virology, Heidelberg University Hospital, Heidelberg, Germany.
Niklas M WeidnerDepartment of Infectious Diseases, Virology, Heidelberg University, Heidelberg, Germany.
Melisa OensalDepartment of Geriatric Psychiatry, Medical Faculty Mannheim, Central Institute of Mental Health, Heidelberg University, Mannheim, Germany.
Lutz FroelichDepartment of Geriatric Psychiatry, Medical Faculty Mannheim, Central Institute of Mental Health, Heidelberg University, Mannheim, Germany.
Claudia BeiselDepartment of Clinical Infectious Diseases, Tropical Medicine, Heidelberg, Germany.
Lucrezia HausnerDepartment of Geriatric Psychiatry, Medical Faculty Mannheim, Central Institute of Mental Health, Heidelberg University, Mannheim, Germany.
Viet Loan Dao ThiChica and Heinz Schaller Research Group, Center of Infectious Diseases, Virology, Heidelberg University Hospital, Heidelberg, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Hepatitis E virus (HEV) exposure has been linked to neurologic manifestations and dementia. This study aims to clarify a possible association between HEV and Alzheimer's disease (AD). Methods: We performed a single-center retrospective case-control study of 453 cognitively impaired adults from southern Germany, comparing anti-HEV IgG seropositivity between patients with AD and those with non-AD cognitive impairment. Associations were evaluated using chi-square testing and multivariable logistic regression, including age-stratified analyses. Results: Overall HEV IgG seroprevalence was higher in the AD group than in the non-AD group (44.5% vs. 37.7%, Conclusion: These findings suggest that anti-HEV antibodies are more frequent in younger elderly AD patients compared with cognitively impaired individuals of the same age without AD, raising the hypothesis that prior HEV infection may represent a candidate environmental risk factor for AD.

Indexed as

age-stratifiedAlzheimer’s diseasecognitive impairmenthepatitis E virusseroprevalence

Identifiers

PMID42182563
PMCPMC13190613

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.