Evidence map›Paper›PMID 42182497›Full record

ArticlebioRxiv : the preprint server for biology2026

WATER reveals heterochrony of molecular programs underlies developmental failure caused by minor spliceosome inhibition.

Saren M Springer, Abigail R Boria, Kyle D Drake, Kevon O Afriyie, Kaitlin N Girardini, Taveena Konakanchi, Isabella Stevens, Nicolas Camacho, Tomas Lopes, Rahul N Kanadia

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Saren M SpringerDepartment of Physiology and Neurobiology, University of Connecticut, Storrs, CT 06269, USA.ORCID 0000-0002-0648-649X
Abigail R BoriaDepartment of Physiology and Neurobiology, University of Connecticut, Storrs, CT 06269, USA.
Kyle D DrakeStem Cell and Regenerative Biology Program and Division of Hematology/Oncology, Children's Hospital Boston, Howard Hughes Medical Institute, Boston, MA 02115, USA.
Kevon O AfriyieDepartment of Physiology and Neurobiology, University of Connecticut, Storrs, CT 06269, USA.
Kaitlin N GirardiniDepartment of Physiology and Neurobiology, University of Connecticut, Storrs, CT 06269, USA.
Taveena KonakanchiDepartment of Physiology and Neurobiology, University of Connecticut, Storrs, CT 06269, USA.
Isabella StevensDepartment of Physiology and Neurobiology, University of Connecticut, Storrs, CT 06269, USA.
Nicolas CamachoDepartment of Physiology and Neurobiology, University of Connecticut, Storrs, CT 06269, USA.
Tomas LopesDepartment of Plant, Soil and Microbial Sciences, Michigan State University, Lansing, MI 48824, USA.
Rahul N KanadiaDepartment of Physiology and Neurobiology, University of Connecticut, Storrs, CT 06269, USA.

Funding

Understanding the role of minor intron splicing in cortical developmentR01NS102538 · NINDS · UNIVERSITY OF CONNECTICUT STORRS · PI KANADIA, RAHUL N · 2018 to 2022
$1.8M
NINDS NIH HHS R01 NS102538
6 · The paper itself

Abstract

The final limb structure reflects coordinated deployment of molecular programs, defined not only by which genes are expressed but when they are activated and silenced across time. Existing omics analyses obscure the temporal unfolding of these programs and conflate program identity with deployment timing by assuming temporal equivalence between conditions. We developed

Identifiers

PMID42182497
PMCPMC13192996

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.