Evidence map›Paper›PMID 42182495›Full record

ArticlebioRxiv : the preprint server for biology2026

Protein Stability, Turnover Kinetics, and Abundance Constrain the Scaling of Protein Interaction Networks.

Muskan Goel, Daniel A Nissley, Xavier Castellanos-Girouard, Charles P Kuntz, Yiqing Wang, M Shahid Mukhtar, Adrian Serohijos, Jonathan P Schlebach

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Muskan GoelThe James Tarpo Jr. and Margaret Tarpo Department of Chemistry, Purdue University, West Lafayette, IN, USA.
Daniel A NissleyNational Synthesis Center for Emergence in the Molecular and Cellular Sciences, National Science Foundation, USA.ORCID 0000-0003-0550-9394
Xavier Castellanos-GirouardDépartement de Biochimie, Université de Montréal, Montréal, Québec, Canada.
Charles P KuntzThe James Tarpo Jr. and Margaret Tarpo Department of Chemistry, Purdue University, West Lafayette, IN, USA.
Yiqing WangDepartment of Genetics and Biochemistry, Clemson University, Clemson, SC, USA.
M Shahid MukhtarDepartment of Genetics and Biochemistry, Clemson University, Clemson, SC, USA.ORCID 0000-0002-1104-6931
Adrian SerohijosDépartement de Biochimie, Université de Montréal, Montréal, Québec, Canada.ORCID 0000-0001-8369-982X
Jonathan P SchlebachThe James Tarpo Jr. and Margaret Tarpo Department of Chemistry, Purdue University, West Lafayette, IN, USA.ORCID 0000-0003-0955-7633

Funding

Molecular Mechanisms of Membrane Protein Misfolding and Quality Control in Cellular ProteostasisR35GM152086 · NIGMS · PURDUE UNIVERSITY · PI Jonathan Patrick Schlebach · 2024 to 2026
$1.5M
NIGMS NIH HHS R35 GM152086
6 · The paper itself

Abstract

The propensity of proteins to form oligomers is ultimately dictated by their structural configuration(s). Proteins that persist in a discrete conformational state may form a limited number of specific interactions while those that sample a broader structural ensemble may instead associate with a wider array of partners. These intrinsic tendencies potentially constrain the way proteins navigate wider interaction networks. In this work, we aggregated and surveyed a wide variety of biophysical, biochemical, and cellular descriptors of the

Identifiers

PMID42182495
PMCPMC13192815

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.