Evidence map›Paper›PMID 42182476›Full record

ArticlebioRxiv : the preprint server for biology2026

Chemical inactivation of a bacterial immune system de-domesticates a temperate phage and promotes its spread.

Yanyao Cai, Jaka Jakin Lazar, Yun Shi, Biswa P Mishra, Thomas Ve, Anna Dragoš, Joseph P Gerdt

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yanyao CaiDepartment of Chemistry, Indiana University, Bloomington, IN 47405, USA.
Jaka Jakin LazarDepartment of Microbiology, Biotechnical Faculty, University of Ljubljana, Večna pot 111, 1000 Ljubljana, Slovenia.
Yun ShiMedicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville VIC 3052, Australia.
Biswa P MishraInstitute for Biomedicine and Glycomics, Griffith University, Gold Coast, QLD 4215, Australia.
Thomas VeInstitute for Biomedicine and Glycomics, Griffith University, Gold Coast, QLD 4215, Australia.
Anna DragošDepartment of Microbiology, Biotechnical Faculty, University of Ljubljana, Večna pot 111, 1000 Ljubljana, Slovenia.
Joseph P GerdtDepartment of Chemistry, Indiana University, Bloomington, IN 47405, USA.ORCID 0000-0002-0375-4110

Funding

Acquisition of an 800 MHz hybrid solution-/solid-state NMR spectrometerS10OD032431 · OD · TRUSTEES OF INDIANA UNIVERSITY · PI GIEDROC, DAVID P. · 2023 to 2023
$2.0M
NIH HHS S10 OD032431
6 · The paper itself

Abstract

Microbial communities shape hosts and ecosystems, yet the behaviors of these microbes are themselves controlled by mobile genetic elements. These mobile genetic elements (MGEs) compete and influence one another's distributions. For example, many anti-phage immune systems are carried by prophages, plasmids, and integrative and conjugative elements (ICEs). It is unclear how important each of these interference mechanisms is for the spread of different mobile elements. Chemical inhibitors of these mechanisms of inter-MGE competition can clarify their mechanisms and significance in diverse environments. We discovered chemical inhibitors of SpbK-an antiphage defense encoded by an ICE in several strains of

Identifiers

PMID42182476
PMCPMC13192956

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.