Evidence map›Paper›PMID 42182463›Full record

ArticlebioRxiv : the preprint server for biology2026

Aberrant CD4

Karl Austin-Muttitt, Bethan R David, Martina Sassi, Ravi Agarwal, Thais S Sabedot, Jeffrey R Jones, Michael S Cuoco, Benjamin J Jenkins, Luke D Roberts, Leo Harris and 12 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Karl Austin-MuttittMolecular Neurobiology, Institute of Life Science, Swansea University Medical School, Swansea, Wales, UK.ORCID 0000-0002-2891-693X
Bethan R DavidMolecular Neurobiology, Institute of Life Science, Swansea University Medical School, Swansea, Wales, UK.ORCID 0009-0008-7482-8501
Martina SassiMolecular Neurobiology, Institute of Life Science, Swansea University Medical School, Swansea, Wales, UK.ORCID 0000-0002-3147-6242
Ravi AgarwalLaboratory of Genetics, Salk Institute for Biological Sciences, La Jolla, San Diego, CA, USA.
Thais S SabedotLaboratory of Genetics, Salk Institute for Biological Sciences, La Jolla, San Diego, CA, USA.ORCID 0000-0002-7813-483X
Jeffrey R JonesLaboratory of Genetics, Salk Institute for Biological Sciences, La Jolla, San Diego, CA, USA.
Michael S CuocoLaboratory of Genetics, Salk Institute for Biological Sciences, La Jolla, San Diego, CA, USA.ORCID 0000-0003-2163-5120
Benjamin J JenkinsInstitute of Life Science, Swansea University Medical School, Swansea, Wales, UK.
Luke D RobertsMolecular Neurobiology, Institute of Life Science, Swansea University Medical School, Swansea, Wales, UK.
Leo HarrisMolecular Neurobiology, Institute of Life Science, Swansea University Medical School, Swansea, Wales, UK.
Natalia KieronczykMolecular Neurobiology, Institute of Life Science, Swansea University Medical School, Swansea, Wales, UK.
Gang HanMolecular Neurobiology, Institute of Life Science, Swansea University Medical School, Swansea, Wales, UK.
Matthew D HitchingsInstitute of Life Science, Swansea University Medical School, Swansea, Wales, UK.ORCID 0000-0002-5527-4709
Paul C DonaghyTranslational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, England, UK.ORCID 0000-0001-7195-4846
Alison J YarnallTranslational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, England, UK.ORCID 0000-0002-3126-9163
Catherine A ThorntonInstitute of Life Science, Swansea University Medical School, Swansea, Wales, UK.ORCID 0000-0002-5153-573X
Biju MohamedUniversity Hospital Llandough, Cardiff and Vale University Health Board, Penarth, Wales, UK.ORCID 0009-0006-9084-307X
Alwena H MorganMolecular Neurobiology, Institute of Life Science, Swansea University Medical School, Swansea, Wales, UK.ORCID 0000-0002-3441-5357
Ffion ThomasParkinson's Clinic, Gorseinon Hospital, Swansea Bay University Health Board, Swansea, Wales, UK.
Nicholas JonesInstitute of Life Science, Swansea University Medical School, Swansea, Wales, UK.
Fred H GageLaboratory of Genetics, Salk Institute for Biological Sciences, La Jolla, San Diego, CA, USA.ORCID 0000-0002-0938-4106
Jeffrey S DaviesMolecular Neurobiology, Institute of Life Science, Swansea University Medical School, Swansea, Wales, UK.ORCID 0000-0002-4234-0033

Funding

Viral Vector Core (VVC)P30CA014195 · NCI · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI Alan Saghatelian · 1985 to 2026
$82.8M
Project 4: Interrogating and harnessing age-related IFN signaling and innate immunity in HCC prevention and therapyP01AG073084 · NIA · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · PI PETER D. ADAMS, GERALD SHADEL · 2021 to 2026
$13.6M
San Diego Nathan Shock CenterP30AG068635 · NIA · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI SHADEL, GERALD · 2020 to 2024
$6.0M
A Hybrid Quadrupole-Orbitrap LC/MSS10OD021815 · OD · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI SAGHATELIAN, ALAN · 2016 to 2016
$580k
NCI NIH HHS P30 CA014195NIA NIH HHS P01 AG073084NIA NIH HHS P30 AG068635NIH HHS S10 OD021815
6 · The paper itself

Abstract

T cells modulate disease associated neuroinflammation in Parkinson's disease (PD). We report that circulating CD4

Identifiers

PMID42182463
PMCPMC13192686

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.