Evidence map›Paper›PMID 42182435›Full record

ArticlebioRxiv : the preprint server for biology2026

A Bacterial Natural Product Reshapes Phyllosphere Microbiome Composition by Blocking Carotenoid Biosynthesis.

Mike Wallace, Madelyn L Allen, Talia L Karasov, Aaron W Puri

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Mike WallaceDepartment of Chemistry, University of Utah, Salt Lake City, Utah, USA.ORCID 0000-0003-1866-2195
Madelyn L AllenSchool of Biological Sciences, University of Utah, Salt Lake City, Utah, USA.ORCID 0009-0006-1370-5079
Talia L KarasovSchool of Biological Sciences, University of Utah, Salt Lake City, Utah, USA.ORCID 0000-0002-3592-6597
Aaron W PuriDepartment of Chemistry, University of Utah, Salt Lake City, Utah, USA.ORCID 0000-0002-6378-678X

Funding

TRAINING PROGRAM IN GENETICST32GM007464 · NIGMS · UNIVERSITY OF UTAH · PI GRUNWALD, DAVID J., STANFIELD, GILLIAN · 1985 to 2020
$6.1M
Methylotrophs: underexplored bacteria for discovering novel natural products and biochemistryR35GM147018 · NIGMS · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Aaron Webster Puri · 2022 to 2026
$1.9M
Identifying limitations on microbial host jumpsR35GM150722 · NIGMS · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Talia Karasov · 2023 to 2026
$1.5M
NIGMS NIH HHS R35 GM147018NIGMS NIH HHS R35 GM150722NIGMS NIH HHS T32 GM007464
6 · The paper itself

Abstract

The microbial communities that inhabit the phyllosphere, the above-ground portion of plants, are important for plant growth and resilience. However, the natural products that mediate interactions among these organisms and with their environment remain understudied, limiting our molecular-level understanding of how phyllosphere microbial communities are structured and maintained. Natural product-mediated microbial competition is typically associated with growth inhibition, but may also occur through other mechanisms in these communities. Many bacteria produce pigments to mitigate oxidative stress, and here we identify listianol, a previously undescribed natural product that inhibits the pigmentation of diverse bacteria. Listianol blocks carotenoid biosynthesis by targeting the desaturases CrtN and CrtI. This activity sensitizes normally pigmented bacteria to UVB radiation

Identifiers

PMID42182435
PMCPMC13192835

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.