Evidence map›Paper›PMID 42182430›Full record

ArticlebioRxiv : the preprint server for biology2026

Longitudinal Alterations in Sleep EEG Biomarkers of Memory Consolidation in Middle-Aged and Older Adults.

Destiny E Berisha, Abhishek Dave, Negin Sattari, Miranda G Chappel-Farley, Kate E Sprecher, Jason Bock, Brady A Riedner, Ethan Moran Grover, Erin M Jonaitis, Henrik Zetterberg and 3 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Destiny E BerishaDepartment of Neurobiology and Behavior, University of California, Irvine, CA, USA.ORCID 0000-0002-9554-9666
Abhishek DaveDepartment of Cognitive Sciences, University of California, Irvine, CA, USA.
Negin SattariDepartment of Psychiatry and Human Behavior, University of California, Irvine, CA, USA.
Miranda G Chappel-FarleyDepartment of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.ORCID 0000-0003-1349-0507
Kate E SprecherNeuroscience Training Program, University of Wisconsin-Madison, Madison, WI, USA.
Jason BockDepartment of Neurobiology and Behavior, University of California, Irvine, CA, USA.
Brady A RiednerDepartment of Psychiatry, University of Wisconsin-Madison, Madison, WI, USA.
Ethan Moran GroverUniversity of Wisconsin-Madison, Madison, WI, USA.
Erin M JonaitisSchool of Nursing, University of Wisconsin-Madison, Madison, WI, USA.
Henrik ZetterbergInstitute of Neuroscience and Physiology, University of Gothenburg, Gothenburg, Sweden.
Barbara B BendlinWisconsin Alzheimer's Disease Research Center, University of Wisconsin-Madison, Madison, WI, USA.
Bryce A ManderCenter for the Neurobiology of Learning and Memory, University of California, Irvine, CA, USA.
Ruth M BencaDepartment of Psychiatry and Behavioral Medicine, Wake Forest University, Winston-Salem, NC, USA.

Funding

Wisconsin Registry for Alzheimer's Prevention: Sex Differences in DNA MethylationR01AG027161 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI Nathaniel Ark Chin, Sterling C Johnson · 2007 to 2026
$35.6M
Institutional Clinical and Translational Science AwardUL1TR000427 · NCATS · UNIVERSITY OF WISCONSIN-MADISON · PI DREZNER, MARC KENNETH · 2012 to 2016
$32.2M
The Longitudinal Course of Neural Function and Amyloid in People At Risk for ADR01AG021155 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI Sterling C Johnson · 2004 to 2026
$27.0M
Wisconsin Alzheimer's Disease Research CenterP50AG033514 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI ASTHANA, SANJAY · 2009 to 2018
$16.2M
White matter degeneration: biomarkers in preclinical Alzheimer's DiseaseR01AG037639 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI BENDLIN, BARBARA BRIGITTA · 2012 to 2023
$5.3M
Apnea and local sleep: Mechanism and intervention in preclinical Alzheimer'sR56AG052698 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI BENCA, RUTH M, BENDLIN, BARBARA BRIGITTA · 2016 to 2016
$748k
Relationships between local and global mechanisms of sleep apnea, Alzheimer's disease biomarkers, and memory impairment in cognitively asymptomatic older adultsK01AG068353 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI MANDER, BRYCE A. · 2020 to 2024
$636k
Cerebrovascular and neurophysiological mechanisms of sleep-dependent memory impairment in older adults at risk for Alzheimer's diseaseF31AG084308 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI BERISHA, DESTINY · 2024 to 2025
$82k
Identifying sleep targets for intervention and detection of preclinical ADF31AG048732 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI SPRECHER, KATE · 2015 to 2016
$63k
NCATS NIH HHS UL1 TR000427NIA NIH HHS F31 AG048732NIA NIH HHS F31 AG084308NIA NIH HHS K01 AG068353NIA NIH HHS P50 AG033514NIA NIH HHS R01 AG021155NIA NIH HHS R01 AG027161NIA NIH HHS R01 AG037639NIA NIH HHS R56 AG052698
6 · The paper itself

Abstract

The precise coordination of slow oscillations (SO) and sleep spindles during non-rapid eye movement (NREM) sleep supports memory consolidation and may serve as a sensitive marker of cognitive aging. However, longitudinal changes in their oscillatory dynamics in midlife and older age remain poorly understood. Using polysomnography with high-density EEG at two timepoints over ~2.5 years, we examined changes in local NREM slow wave (SW), sleep spindle (occurring in the 11-16 Hz sigma range), and SO-sigma coupling strength in cognitively unimpaired middle-aged to older adults at risk for Alzheimer's disease. Fronto-central SO-sigma power coupling strength significantly declined over time, independent of changes in multiple measures of SW and sleep spindle expression. Local declines in multiple sleep spindle measures were also observed. Greater baseline levels of cerebrospinal fluid (CSF) neurogranin, a postsynaptic protein abundantly expressed in the dendritic spines of the hippocampus and cerebral cortex and implicated in calcium-dependent synaptic plasticity, predicted the magnitude of longitudinal decline in SO-fast sigma coupling strength, which in turn predicted episodic memory performance changes. These findings suggest that longitudinal changes in local sleep oscillatory dynamics are related to decreased synaptic integrity and may serve as an early indicator of memory decline in older adults at risk for Alzheimer's disease.

Identifiers

PMID42182430
PMCPMC13192916

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.