Evidence map›Paper›PMID 42182429›Full record

ArticlebioRxiv : the preprint server for biology2026

Spatiotemporal dynamics of adoptively transferred stem-like CD8

Dalton Hermans, Sloane C Fussell, Andrei Ramirez-Valdez, Sam Shepard, Remi Poulard, Sonia Zumalave, Benjamin Sievers, Christopher M Garliss, Vincent L Coble, Geoffrey M Lynn and 3 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Dalton HermansVaccine Research Center, 40 Convent Drive, National Institutes of Health.ORCID 0000-0002-7913-1198
Sloane C FussellVaccine Research Center, 40 Convent Drive, National Institutes of Health.ORCID 0009-0009-8628-8335
Andrei Ramirez-ValdezVaccine Research Center, 40 Convent Drive, National Institutes of Health.
Sam ShepardVaccine Research Center, 40 Convent Drive, National Institutes of Health.ORCID 0000-0001-5255-1726
Remi PoulardEuropean Bioinformatics Institute (EMBL-EBI), Hinxton, UK.ORCID 0009-0002-3161-1325
Sonia ZumalaveEuropean Bioinformatics Institute (EMBL-EBI), Hinxton, UK.ORCID 0000-0002-2108-1861
Benjamin SieversVaccine Research Center, 40 Convent Drive, National Institutes of Health.ORCID 0000-0002-9681-9082
Christopher M GarlissVaccine Research Center, 40 Convent Drive, National Institutes of Health.ORCID 0009-0009-8030-6467
Vincent L CobleBarinthus Biotherapeutics North America.
Geoffrey M LynnBarinthus Biotherapeutics North America.
Andrew S IshizukaBarinthus Biotherapeutics North America.ORCID 0000-0002-3024-7536
Isidro Cortes-CirianoEuropean Bioinformatics Institute (EMBL-EBI), Hinxton, UK.ORCID 0000-0002-2036-494X
Robert A SederVaccine Research Center, 40 Convent Drive, National Institutes of Health.ORCID 0000-0003-3133-0849

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Adoptive cell therapy (ACT) of tumor-specific T cells can improve survival in a subset of cancer patients. Current ACT approaches may be limited by using highly differentiated T cells which can be inhibited by an immunosuppressive tumor microenvironment (TME). Here, we developed an approach to optimize ACT and used spatial transcriptomics to show how stem-like and effector CD8

Identifiers

PMID42182429
PMCPMC13192939

What OpenQuestion holds

Textmetadata
LicenceCC0
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.