Evidence map›Paper›PMID 42182421›Full record

ArticlebioRxiv : the preprint server for biology2026

Reduction in Hepatic Phosphatidylcholine Biosynthesis Promotes MASH Through Copper Deficiency.

Jaclyn E Welles, James P Garifallou, Michael V Gonzalez, Dominic Santoleri, Feroza K Choudhury, Gina M DeNicola, Ryan W Martin, Chang Jiang, Jaehee Kim, Gen Li and 9 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Jaclyn E WellesDepartment of Cancer Biology, Philadelphia, Pennsylvania, USA.
James P GarifallouCenter for Applied Genomics Research Institute, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
Michael V GonzalezCenter for Applied Genomics Research Institute, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
Dominic SantoleriDepartment of Physiology Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
Feroza K ChoudhuryDepartment of Metabolism and Physiology, Tampa, Florida, USA.
Gina M DeNicolaDepartment of Metabolism and Physiology, Tampa, Florida, USA.
Ryan W MartinDepartment of Molecular Oncology, Moffitt Cancer Center, Tampa, Florida, USA.
Chang JiangDepartment of Molecular Oncology, Moffitt Cancer Center, Tampa, Florida, USA.
Jaehee KimDepartment of Chemistry, Princeton University, Princeton, New Jersey, USA.
Gen LiDepartment of Chemistry, Princeton University, Princeton, New Jersey, USA.
Yuichi AkiDepartment of Chemistry, Princeton University, Princeton, New Jersey, USA.
Christopher J ChangDepartment of Chemistry, Princeton University, Princeton, New Jersey, USA.
David LiDivision of Gastroenterology and Hepatology, Department of Medicine, Philadelphia, Pennsylvania, USA.
Rebecca G WellsDivision of Gastroenterology and Hepatology, Department of Medicine, Philadelphia, Pennsylvania, USA.
Yang XiaoDivision of Endocrinology, Diabetes & Metabolism, Department of Medicine, Philadelphia, Pennsylvania, USA.
Jiayu ZhangDivision of Endocrinology, Diabetes & Metabolism, Department of Medicine, Philadelphia, Pennsylvania, USA.
Mitchell A LazarDivision of Endocrinology, Diabetes & Metabolism, Department of Medicine, Philadelphia, Pennsylvania, USA.
Donita C BradyDepartment of Cancer Biology, Philadelphia, Pennsylvania, USA.ORCID 0000-0002-2786-2802
Paul M TitchenellDepartment of Physiology Perelman School of Medicine, Philadelphia, Pennsylvania, USA.

Funding

Molecular Imaging Probes To Study Redox BiologyR01GM079465 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI Christopher J. Chang · 2006 to 2026
$7.8M
Molecular and Cellular Mechanisms of Copper-Dependent Nutrient Signaling and MetabolismR35GM124749 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI Donita C Brady · 2017 to 2026
$4.6M
Hepatic mTORC1 Signaling and the Regulation of Lipid HomeostasisR01DK125497 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI TITCHENELL, PAUL MICHAEL · 2021 to 2024
$1.7M
Functional identification of non-coding variants associated with metabolic dysfunction-associated steatotic liver diseaseK01DK138281 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI yang Xiao · 2025 to 2026
$292k
NIDDK NIH HHS K01 DK138281NIDDK NIH HHS R01 DK125497NIGMS NIH HHS R01 GM079465NIGMS NIH HHS R35 GM124749
6 · The paper itself

Abstract

Metabolic dysfunction-associated steatohepatitis (MASH) is a progressive liver disease for which the mechanisms linking lipid dysregulation to fibrosis remain poorly defined. Hepatic phosphatidylcholine (PC) content is reduced in MASH, but how this alteration drives disease progression is unclear. Here, we identify a role for copper (Cu) homeostasis as a downstream effector of impaired PC biosynthesis. Using single-nucleus RNA sequencing in complementary genetic and dietary mouse models, we found that reduced hepatic PC is associated with marked depletion of hepatic Cu and a concomitant increase in circulating Cu, indicating disrupted Cu distribution. Mechanistically, PC depletion impaired plasma membrane localization of the high-affinity Cu transporter CTR1 (

Identifiers

PMID42182421
PMCPMC13192769

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.