Evidence map›Paper›PMID 42182385›Full record

ArticlebioRxiv : the preprint server for biology2026

Single-cell RNA sequencing reveals that host Glutamine Metabolism Inhibition Enhances Macrophage Phagocytosis of

Yingli Shi, Lesly Rodriguez Vicens, Micheal Teve, Barbara Slusher, William R Bishai, Sadiya Parveen-Nesson

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yingli ShiDepartment of Microbiology and Immunology, Louisiana State University Health Sciences Center-Shreveport, Shreveport, Louisiana, 71103, USA.ORCID 0000-0002-0569-9872
Lesly Rodriguez VicensDepartment of Microbiology and Immunology, Louisiana State University Health Sciences Center-Shreveport, Shreveport, Louisiana, 71103, USA.
Micheal TeveDepartment of Microbiology and Immunology, Louisiana State University Health Sciences Center-Shreveport, Shreveport, Louisiana, 71103, USA.
Barbara SlusherJohns Hopkins School of Medicine, Baltimore, MD 21287, USA.ORCID 0000-0001-9814-4157
William R BishaiJohns Hopkins School of Medicine, Baltimore, MD 21287, USA.ORCID 0000-0002-8734-4118
Sadiya Parveen-NessonDepartment of Microbiology and Immunology, Louisiana State University Health Sciences Center-Shreveport, Shreveport, Louisiana, 71103, USA.ORCID 0000-0003-4737-204X

Funding

The role of adipocyte-driven inflammation and leptin pathway in pulmonary viral infections caused by SARS-CoV-2 and influenza A virusesP20GM130555 · NIGMS · LOUISIANA STATE UNIV A&M COL BATON ROUGE · PI Alexandra Noel · 2019 to 2026
$19.9M
Project 4-Tracking cytomegalovirus-primed long-lived NK cells in salivary glandP20GM134974 · NIGMS · LOUISIANA STATE UNIV HSC SHREVEPORT · PI ANDREW D YUROCHKO · 2021 to 2026
$15.0M
Glutamine metabolism inhibitors for TB and TB-HIV: dual action as host-directed therapies with antibacterial activityR01AI155602 · NIAID · JOHNS HOPKINS UNIVERSITY · PI BISHAI, WILLIAM RAMSES · 2020 to 2024
$4.0M
The 'Career MODE' Program: Careers through Mentoring and training in Omics and Data for Early-stage investigatorsR25GM143298 · NIGMS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI IONITA, IULIANA, RE, DIANE BERENGERE · 2021 to 2025
$2.3M
NIAID NIH HHS R01 AI155602NIGMS NIH HHS P20 GM130555NIGMS NIH HHS P20 GM134974NIGMS NIH HHS R25 GM143298
6 · The paper itself

Abstract

Macrophages are crucial for host defense against the pathogen. However, pathogens such as

Indexed as

glutamine inhibitionhost-directed therapyimmunotherapyMacrophagesTuberculosis

Identifiers

PMID42182385
PMCPMC13192944

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.