Evidence map›Paper›PMID 42182376›Full record

ArticlebioRxiv : the preprint server for biology2026

Active repression of muscle fate preserves neural lineage identity during cerebellum development.

Nurunnabi Mirja Shaikh, Venkata Thulabandu, Akira Inoue, Joshua Paré, Jackie Norrie, Qiong Zhang, Beisi Xu, Xinwei Cao

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Nurunnabi Mirja ShaikhDepartment of Developmental Neurobiology, St. Jude Children's Research Hospital; Memphis, TN 38105, USA.
Venkata ThulabanduDepartment of Developmental Neurobiology, St. Jude Children's Research Hospital; Memphis, TN 38105, USA.
Akira InoueDepartment of Developmental Neurobiology, St. Jude Children's Research Hospital; Memphis, TN 38105, USA.
Joshua ParéDepartment of Developmental Neurobiology, St. Jude Children's Research Hospital; Memphis, TN 38105, USA.
Jackie NorrieDepartment of Developmental Neurobiology, St. Jude Children's Research Hospital; Memphis, TN 38105, USA.
Qiong ZhangCenter for Applied Bioinformatics, St. Jude Children's Research Hospital; Memphis, TN 38105, USA.
Beisi XuCenter for Applied Bioinformatics, St. Jude Children's Research Hospital; Memphis, TN 38105, USA.ORCID 0000-0003-0099-858X
Xinwei CaoDepartment of Developmental Neurobiology, St. Jude Children's Research Hospital; Memphis, TN 38105, USA.ORCID 0000-0003-0651-5243

Funding

Viral Vector Technology (VVTSR)P30CA021765 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI CHARLES ROBERTS · 1985 to 2026
$166.9M
Understanding the developmental progression of subpallial neural progenitor cellsR01NS119760 · NINDS · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI CAO, XINWEI · 2021 to 2024
$1.8M
NCI NIH HHS P30 CA021765NINDS NIH HHS R01 NS119760
6 · The paper itself

Abstract

Cell fate commitment is commonly thought to entail progressive restriction of developmental potential, enforced by passive, heterochromatin-based silencing of alternative lineage programs. Here we show that maintenance of neural identity during cerebellum development instead requires active repression of a starkly divergent fate by the TEAD-INSM1 transcriptional complex. Loss of TEAD1/2 or INSM1 activates the myogenic master regulator

Identifiers

PMID42182376
PMCPMC13192970

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.