Evidence map›Paper›PMID 42182332›Full record

ArticlebioRxiv : the preprint server for biology2026

Mechanical Signaling Regulates DNA Methylation to Maintain Muscle Stem Cell Quiescence.

Pukana Jayaraman, Paige R Deltener, Justice Paintsil, Christian O Abosede, Atreyi Ghatak, Sarah Abrahamson, Chris W D Jurgens, Damien Parrello, Susan Eliazer

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Pukana JayaramanDepartment of Biomedical Sciences, University of North Dakota School of Medicine and Health Sciences, Grand Forks, 58203, USA.ORCID 0000-0002-4905-2261
Paige R DeltenerDepartment of Biomedical Sciences, University of North Dakota School of Medicine and Health Sciences, Grand Forks, 58203, USA.
Justice PaintsilDepartment of Biomedical Sciences, University of North Dakota School of Medicine and Health Sciences, Grand Forks, 58203, USA.ORCID 0009-0001-7358-353X
Christian O AbosedeDepartment of Biomedical Sciences, University of North Dakota School of Medicine and Health Sciences, Grand Forks, 58203, USA.ORCID 0000-0003-1103-775X
Atreyi GhatakDepartment of Biomedical Sciences, University of North Dakota School of Medicine and Health Sciences, Grand Forks, 58203, USA.ORCID 0000-0002-8849-007X
Sarah AbrahamsonDepartment of Biomedical Sciences, University of North Dakota School of Medicine and Health Sciences, Grand Forks, 58203, USA.ORCID 0009-0009-9085-3595
Chris W D JurgensDepartment of Pathology, University of North Dakota School of Medicine and Health Sciences, Grand Forks, 58203, USA.
Damien ParrelloDepartment of Biomedical Sciences, University of North Dakota School of Medicine and Health Sciences, Grand Forks, 58203, USA.ORCID 0009-0003-2554-6819
Susan EliazerDepartment of Biomedical Sciences, University of North Dakota School of Medicine and Health Sciences, Grand Forks, 58203, USA.ORCID 0009-0004-6542-3087

Funding

Research CoresP20GM103442 · NIGMS · UNIVERSITY OF NORTH DAKOTA · PI Donald A. Sens · 2012 to 2026
$53.0M
The role of class IIa Hdac in regulating cell fate choice in early cortical development.P20GM104360 · NIGMS · UNIVERSITY OF NORTH DAKOTA · PI ROCHE, BENJAMIN · 2013 to 2023
$21.1M
Tracking and Evaluation CoreU54GM128729 · NIGMS · UNIVERSITY OF NORTH DAKOTA · PI BASSON, MARC D. · 2018 to 2022
$20.3M
Yersina perstis interactions with macrophagesP20GM113123 · NIGMS · UNIVERSITY OF NORTH DAKOTA · PI COMBS, COLIN K · 2016 to 2025
$19.9M
NIGMS NIH HHS P20 GM103442NIGMS NIH HHS P20 GM104360NIGMS NIH HHS P20 GM113123NIGMS NIH HHS U54 GM128729
6 · The paper itself

Abstract

Skeletal muscle stem cells (MuSCs) reside within a mechanically dynamic niche where they integrate biophysical and biochemical cues to maintain quiescence. Here, we show that substrate stiffness and RhoA-dependent signaling regulate MuSC fate. MuSCs cultured on soft matrices or depleted of RhoA exhibit altered morphology, diminished actomyosin organization, and undergo premature activation. Loss of

Indexed as

DNA methylationDnmt3AEpigenetic regulationMechanotransductionRhoA signalingSkeletal muscle stem cells (MuSCs)Stem cell quiescence

Identifiers

PMID42182332
PMCPMC13192721

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.