In one paragraphArticle in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
14 authors.
Sebastian Jojoa-CruzDepartment of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, 92037, USA.ORCID 0000-0002-4392-3898 Nolan P JacobDepartment of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.ORCID 0000-0002-1115-9223 Weiyi TangDepartment of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, 92037, USA.ORCID 0009-0003-4601-6542 Mio MurakosoDepartment of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, 92037, USA.ORCID 0009-0002-0021-5370 Minghao ZhangDepartment of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, 92037, USA.ORCID 0009-0007-3485-6324 Jiayi LiDepartment of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, 92037, USA.ORCID 0009-0006-5293-8238 Huong T KratochvilDepartment of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.ORCID 0000-0001-8039-6823 Marco MravicDepartment of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, 92037, USA.ORCID 0000-0001-6294-1824 Funding
Pacific Northwest Center for Cryo-EM: Equipment SupplementR24GM154185 · NIGMS · OREGON HEALTH & SCIENCE UNIVERSITY · PI James E Evans, CLAUDIA SUSANA LOPEZ · 2024 to 2026
$21.5MCell Specific Perturbations of the Proteome in Alzheimer's DiseaseR01AG075862 · NIA · SCRIPPS RESEARCH INSTITUTE, THE · PI MAXIMOV, ANTON, PETRASCHECK, MICHAEL · 2021 to 2025
$6.6MAnalysis of protein interactions in neurodegenerative diseaseR01AG077046 · NIA · SCRIPPS RESEARCH INSTITUTE, THE · PI John R Yates III · 2022 to 2026
$3.5MThe CFTR InteractomeR01HL165168 · NHLBI · SCRIPPS RESEARCH INSTITUTE, THE · PI YATES III, JOHN R · 2022 to 2025
$2.1MFolding and degradation of membrane proteinsR35GM144146 · NIGMS · MICHIGAN STATE UNIVERSITY · PI Heedeok Hong · 2022 to 2026
$1.5MMolecular and Cellular Biophysics Training GrantT32GM148376 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Matthew R Redinbo, Qi Zhang · 2024 to 2026
$1.4MProton Conduction Pathways in Proton Channel ProteinsR00GM138753 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI KRATOCHVIL, HUONG TRAN · 2023 to 2025
$747kDe novo design of small-molecule-binding proteinsR00GM135519 · NIGMS · DANA-FARBER CANCER INST · PI POLIZZI, NICHOLAS · 2022 to 2024
$747kNHLBI NIH HHS R01 HL165168NIA NIH HHS R01 AG075862NIA NIH HHS R01 AG077046NIGMS NIH HHS R00 GM135519NIGMS NIH HHS R00 GM138753NIGMS NIH HHS R24 GM154185NIGMS NIH HHS R35 GM144146NIGMS NIH HHS T32 GM148376
6 · The paper itselfAbstract
Transmembrane (TM) proteins play essential roles in biology as transporters, ion channels, chaperones, enzymes, and mediators of signal transduction. However, membrane proteins often suffer from inefficient folding and intrinsic instability. Misfolding in cells can cause numerous loss-of-function pathologies. Likewise, denaturation upon purification in the laboratory is a critical barrier to structure determination and characterization of key biochemical mechanisms. Generalizable strategies to stabilize membrane proteins remain limited. Here, we developed an informatics-based
Identifiers
PMID42182326
PMCPMC13192813
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