Evidence map›Paper›PMID 42182308›Full record

ArticlebioRxiv : the preprint server for biology2026

Engineering a Matrix-Preserving Vascular dECM Platform with Tunable Stiffness for

Yuna Heo, Rhonda Drewes, Se-Hwan Lee, Yongho Bae, Su Chin Heo

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Yuna HeoMcKay Orthopaedic Research Laboratory, Department of Orthopaedic Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
Rhonda DrewesDepartment of Pathology and Anatomical Sciences, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, New York 14203, USA.
Se-Hwan LeeMcKay Orthopaedic Research Laboratory, Department of Orthopaedic Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
Yongho BaeDepartment of Pathology and Anatomical Sciences, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, New York 14203, USA.ORCID 0000-0002-1838-1652
Su Chin HeoMcKay Orthopaedic Research Laboratory, Department of Orthopaedic Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.ORCID 0000-0003-2771-5076

Funding

Research Project 2P50AR080581 · NIAMS · UNIVERSITY OF PENNSYLVANIA · PI LOUIS J SOSLOWSKY · 2023 to 2026
$7.9M
Biomimetic Vascular Matrix for Vascular Smooth Muscle Cell Mechanobiology and PathologyR01HL163168 · NHLBI · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI Yongho Bae, Su Chin Heo · 2023 to 2026
$2.2M
Preserving chromatin nano-structure to enhance chondrocyte therapeutic potential for cartilage repairR01AR079224 · NIAMS · UNIVERSITY OF PENNSYLVANIA · PI Su Chin Heo, Melike Lakadamyali · 2022 to 2026
$2.0M
NHLBI NIH HHS R01 HL163168NIAMS NIH HHS P50 AR080581NIAMS NIH HHS R01 AR079224
6 · The paper itself

Abstract

Pathologic arterial stiffening is a hallmark of vascular disease that contributes to maladaptive vascular remodeling and neointimal hyperplasia through vascular smooth muscle cell (VSMC) phenotypic switching. Yet, because vascular disease progression is governed by both biomechanical and extracellular matrix (ECM) alterations, existing

Indexed as

MechanotransductionTunable stiffnessVascular dECMVascular remodelingVascular smooth muscle cells

Identifiers

PMID42182308
PMCPMC13192848

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.