Evidence map›Paper›PMID 42182281›Full record

ArticlebioRxiv : the preprint server for biology2026

Siglec-G on B cells restrains the germinal center response by controlling T cell help during positive selection.

Jhon R Enterina, Sung-Yao Lin, Liany Luna-Dulcey, Susmita Sarkar, Edward N Schmidt, Zeinab Jame-Chenarboo, Kennedy Chisholm, Arbab Ul Haq, Shu Luo, Chris D St Laurent and 4 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Jhon R EnterinaDepartment of Medical Microbiology and Immunology, University of Alberta, Edmonton, Alberta T6G 2E1, Canada.
Sung-Yao LinDepartment of Medical Microbiology and Immunology, University of Alberta, Edmonton, Alberta T6G 2E1, Canada.
Liany Luna-DulceyDepartment of Chemistry, University of Alberta, Edmonton, Alberta T6G 2G2, Canada.
Susmita SarkarDepartment of Chemistry, University of Alberta, Edmonton, Alberta T6G 2G2, Canada.
Edward N SchmidtDepartment of Chemistry, University of Alberta, Edmonton, Alberta T6G 2G2, Canada.
Zeinab Jame-ChenarbooDepartment of Chemistry, University of Alberta, Edmonton, Alberta T6G 2G2, Canada.
Kennedy ChisholmDepartment of Medical Microbiology and Immunology, University of Alberta, Edmonton, Alberta T6G 2E1, Canada.
Arbab Ul HaqDepartment of Biochemistry, University of Alberta, Edmonton, Alberta T6G 2H7, Canada.
Shu LuoDepartment of Biochemistry, University of Alberta, Edmonton, Alberta T6G 2H7, Canada.
Chris D St LaurentDepartment of Medical Microbiology and Immunology, University of Alberta, Edmonton, Alberta T6G 2E1, Canada.
Theo AtaeiDepartment of Medicine, University of Alberta, Edmonton, Alberta, T6G 2B7, Canada.
Fabrizio GiulianiDepartment of Medicine, University of Alberta, Edmonton, Alberta, T6G 2B7, Canada.
Olivier JulienDepartment of Medical Microbiology and Immunology, University of Alberta, Edmonton, Alberta T6G 2E1, Canada.
Matthew S MacauleyDepartment of Medical Microbiology and Immunology, University of Alberta, Edmonton, Alberta T6G 2E1, Canada.ORCID 0000-0003-4579-1048

Funding

Role of Siglec-10/G as a tumor suppressor in B-cellsR21AI128598 · NIAID · UNIVERSITY OF ALBERTA · PI MACAULEY, MATTHEW SCOTT · 2017 to 2018
$354k
NIAID NIH HHS R21 AI128598
6 · The paper itself

Abstract

The germinal center (GC) reaction requires tight regulation of B cell and T follicular helper (Tfh) cell interactions to ensure B cell expansion and antibody affinity maturation, while preventing oncogenesis. However, regulatory mechanisms fine-tuning B-T cell interactions within the GC to prevent aberrant activation and proliferation remain incompletely understood. Here, we identify Siglec-G, the mouse ortholog of human Siglec-10, as an immune checkpoint that restrains the GC by dampening B-T cell interactions. Selective and temporal ablation of Siglec-G on B cells after immunization triggers GC hyperplasia and enhanced plasma cell and antibody output. While Siglec-G is dispensable in B cell receptor (BCR)-mediated processes, it acts as an intrinsic inhibitory receptor of B-T cell interactions in the GC, ultimately limiting Myc and mTORC activation within positively selected GC B cells.

Indexed as

B cellsgerminal centerglycanssialic acidSiglec-G

Identifiers

PMID42182281
PMCPMC13192747

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.