Evidence map›Paper›PMID 42182264›Full record

ArticlebioRxiv : the preprint server for biology2026

Disordered protein COSA-2 maintains crossover-specific repair compartments to ensure meiotic crossover maturation.

Celja J Uebel, Dahlia Y Deng, Yumi Kim, Anne M Villeneuve

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Celja J UebelDepartment of Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305, USA.ORCID 0000-0002-0362-1238
Dahlia Y DengDepartment of Biology, Johns Hopkins University, Baltimore, MD 21218, USA.ORCID 0000-0001-8822-6909
Yumi KimDepartment of Biology, Johns Hopkins University, Baltimore, MD 21218, USA.ORCID 0000-0002-6110-5936
Anne M VilleneuveDepartment of Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305, USA.ORCID 0000-0001-5193-2076

Funding

Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Aric L Daul, Ann E. Rougvie · 2012 to 2026
$7.5M
Meiotic Chromosome Inheritance in C. elegansR35GM126964 · NIGMS · STANFORD UNIVERSITY · PI ANNE M VILLENEUVE · 2018 to 2026
$6.2M
Molecular Control of Meiotic Chromosome DynamicsR35GM124895 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI Yumi Kim · 2017 to 2026
$4.3M
Multiparametric deep tissue microscope for in vivo and in vitro imagingS10OD032300 · OD · STANFORD UNIVERSITY · PI O'BRIEN, LUCY ERIN · 2022 to 2022
$600k
Formation and Regulation of Meiotic CrossoversF32GM153100 · NIGMS · STANFORD UNIVERSITY · PI UEBEL, CELJA · 2024 to 2025
$77k
NIGMS NIH HHS F32 GM153100NIGMS NIH HHS R35 GM124895NIGMS NIH HHS R35 GM126964NIH HHS P40 OD010440NIH HHS S10 OD032300
6 · The paper itself

Abstract

Faithful genome inheritance during meiosis relies on crossover repair of double-strand DNA breaks (DSBs) to connect homologous chromosomes and direct their proper segregation. The formation of crossover-specific recombination intermediates and accumulation of pro-crossover factors occurs at an extremely limited subset of DSB sites, necessitating that the subset of recombination sites designated to become crossovers reliably mature into crossovers. Here we identify

Indexed as

C. eleganschromosome inheritancecrossoverDNA repairmeiosis

Identifiers

PMID42182264
PMCPMC13192651

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.