Evidence map›Paper›PMID 42182245›Full record

ArticlebioRxiv : the preprint server for biology2026

Virtual screening and zebrafish phenotype-based evaluation argues against repurposing 4-phenylbutyrate for STXBP1-related disorders.

Aline Frick, Paige Whyte-Fagundes, Scott C Baraban

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

Aline FrickDepartment of Neurological Surgery & Weill Institute for Neuroscience, University of California, San Francisco, CA, USA.
Paige Whyte-FagundesDepartment of Neurological Surgery & Weill Institute for Neuroscience, University of California, San Francisco, CA, USA.ORCID 0000-0003-4878-9955
Scott C BarabanDepartment of Neurological Surgery & Weill Institute for Neuroscience, University of California, San Francisco, CA, USA.ORCID 0000-0003-1975-9781

Funding

Proteins to Cell SystemsU54NS117170 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ISOM, LORI L., PARENT, JACK M · 2020 to 2024
$11.9M
ZEBRAFISH MODELS FOR DRAVET SYNDROME RESEARCH AND DISCOVERYR01NS096976 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BARABAN, SCOTT C · 2016 to 2024
$3.9M
Gluconeogenic control of Dravet SyndromeR01HD102071 · NICHD · UNIVERSITY OF COLORADO DENVER · PI BARABAN, SCOTT C, PATEL, MANISHA N · 2020 to 2024
$2.5M
Deep Behavioral Phenotyping of Novel Zebrafish Epilepsy ModelsR21NS138525 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BARABAN, SCOTT C · 2024 to 2025
$521k
NICHD NIH HHS R01 HD102071NINDS NIH HHS R01 NS096976NINDS NIH HHS R21 NS138525NINDS NIH HHS U54 NS117170
6 · The paper itself

Abstract

Syntaxin-binding protein 1 (

Indexed as

BehaviorPharmacologySeizureZebrafish

Identifiers

PMID42182245
PMCPMC13192907

What OpenQuestion holds

Textmetadata
LicenceCC0
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.