Evidence map›Paper›PMID 42182241›Full record

ArticlebioRxiv : the preprint server for biology2026

Dysregulation of anti-Ro60 B cell autoreactivity in systemic lupus erythematosus.

Oindrila Rahaman, Carlos Castrillon, Regina Bugrovsky, Raksha Das, Midushi Ghimire, Trinh T P Van, Martin Lin, Sabeena Y Usman, R Toby Amoss, Aakriti Alisha Arora and 3 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Oindrila RahamanDepartment of Medicine, Division of Rheumatology, Lowance Center for Human Immunology, Emory University School of Medicine, Atlanta, GA.ORCID 0000-0001-6632-6837
Carlos CastrillonDepartment of Medicine, Division of Rheumatology, Lowance Center for Human Immunology, Emory University School of Medicine, Atlanta, GA.
Regina BugrovskyDepartment of Medicine, Division of Rheumatology, Lowance Center for Human Immunology, Emory University School of Medicine, Atlanta, GA.
Raksha DasDepartment of Medicine, Division of Rheumatology, Lowance Center for Human Immunology, Emory University School of Medicine, Atlanta, GA.
Midushi GhimireDepartment of Medicine, Division of Rheumatology, Lowance Center for Human Immunology, Emory University School of Medicine, Atlanta, GA.
Trinh T P VanDepartment of Medicine, Division of Rheumatology, Lowance Center for Human Immunology, Emory University School of Medicine, Atlanta, GA.
Martin LinDepartment of Medicine, Division of Rheumatology, Lowance Center for Human Immunology, Emory University School of Medicine, Atlanta, GA.
Sabeena Y UsmanDepartment of Medicine, Division of Rheumatology, Lowance Center for Human Immunology, Emory University School of Medicine, Atlanta, GA.
R Toby AmossDepartment of Medicine, Division of Rheumatology, Lowance Center for Human Immunology, Emory University School of Medicine, Atlanta, GA.
Aakriti Alisha AroraDepartment of Medicine, Division of Rheumatology, Lowance Center for Human Immunology, Emory University School of Medicine, Atlanta, GA.
Arezou KhosroshahiDepartment of Medicine, Division of Rheumatology, Lowance Center for Human Immunology, Emory University School of Medicine, Atlanta, GA.
Frances Eun-Hyung LeeDepartment of Medicine, Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, School of Medicine, Emory University, Atlanta, GA, USA.
Ignacio SanzDepartment of Medicine, Division of Rheumatology, Lowance Center for Human Immunology, Emory University School of Medicine, Atlanta, GA.

Funding

Regulation of B cell Responses in SLE and Other Autoimmune DiseasesU19AI110483 · NIAID · EMORY UNIVERSITY · PI Ignacio E. Sanz · 2014 to 2026
$76.6M
NIAID NIH HHS U19 AI110483
6 · The paper itself

Abstract

To understand the dysregulation of autoreactive B cells in SLE, we tracked Ro60-specific cells in seropositive (SP) and seronegative (SN) patients and healthy donors (HD), using flow cytometry and monoclonal antibodies. Consistent with permissive central tolerance, Ro60

Identifiers

PMID42182241
PMCPMC13192738

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.