Evidence map›Paper›PMID 42182238›Full record

ArticlebioRxiv : the preprint server for biology2026

Protein Response to ACL Injury in Humans Show Early Cartilage Remodeling and Differences by Sex.

Paula A Hernandez, Constance R Chu, Chun-Yuan Huang, Chao Xing, Meenakshi V Venkatachalam, J Lee Pace, Steven B Singleton

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Paula A HernandezDepartment of Orthopaedic Surgery, University of Texas Southwestern Medical Center, Dallas, Texas, USA.ORCID 0000-0002-8785-7351
Constance R ChuDepartment of Orthopaedic Surgery. Stanford University, Stanford, California, United States.ORCID 0000-0002-4998-5846
Chun-Yuan HuangEugene McDermott Center for Human Growth and Development, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Chao XingEugene McDermott Center for Human Growth and Development, University of Texas Southwestern Medical Center, Dallas, Texas, USA.ORCID 0000-0002-1838-0502
Meenakshi V VenkatachalamDepartment of Orthopaedic Surgery, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
J Lee PaceChildren's Health Andrews Institute, Frisco, Texas, United States.ORCID 0000-0003-4530-1838
Steven B SingletonDepartment of Orthopaedic Surgery, University of Texas Southwestern Medical Center, Dallas, Texas, USA.ORCID 0009-0006-4692-0744

Funding

Enhanced Clinical Diagnosis of Early OsteoarthritisR01AR052784 · NIAMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CHU, CONSTANCE R · 2006 to 2015
$4.1M
NIAMS NIH HHS R01 AR052784
6 · The paper itself

Abstract

Objective: Anterior cruciate ligament (ACL) tears increase the risk for developing posttraumatic osteoarthritis (PTOA). Females have greater risk for both. However, studies defining sex-specific protein responses in human cartilage after ACL injury are lacking. We hypothesize that articular cartilage's response to an injurious environment differs depending on sex. Design: We compared the proteomic profiles of Results: From the 2,188 proteins identified, males and females shared 1,121 upregulated and 23 downregulated proteins in injured compared to normal cartilage. Analysis of ECM proteins and enriched pathways revealed mostly similar male and female responses to an injurious environment, with evidence of early cartilage remodeling in both sexes. Nevertheless, more than 240 proteins were affected specifically by sex, and significant sex differences were found in inflammation, ECM-related, and metabolic pathways. Males were enriched mostly in " Conclusion: Articular cartilage shows signs of remodeling soon after ACL injury, even when only exposed to an injurious environment rather than being physically impacted. Sex differences were observed in inflammation, metabolic pathways, and ECM synthesis.

Indexed as

ACLcartilageinjuryproteomicssex differences

Identifiers

PMID42182238
PMCPMC13192974

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.