Evidence map›Paper›PMID 42182229›Full record

ArticlebioRxiv : the preprint server for biology2026

Acute buprenorphine exposure depresses neonatal respiratory chemoreflexes in the presence or absence of naloxone.

Michael Frazure, Khushi Praveen, Elias Sitzmann, Emily Flanigan, Ralph Fregosi

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Michael FrazureDepartment of Physiology, University of Arizona, Tucson, AZ, 85724-5051, USA.ORCID 0000-0002-8775-7692
Khushi PraveenBiomedical Engineering, University of Arizona, Tucson, AZ, 85724-5051, USA.
Elias SitzmannDepartment of Physiology, University of Arizona, Tucson, AZ, 85724-5051, USA.
Emily FlaniganDepartment of Physiology, University of Arizona, Tucson, AZ, 85724-5051, USA.
Ralph FregosiDepartment of Physiology, University of Arizona, Tucson, AZ, 85724-5051, USA.ORCID 0000-0002-6849-7530

Funding

PHYSIOLOGYT32HL007249 · NHLBI · UNIVERSITY OF ARIZONA · PI Brett A Colson, JOHN P KONHILAS · 1985 to 2026
$12.5M
Chronic nicotine and synaptic transmission in brainstem respiratory neuronsR01HD071302 · NICHD · UNIVERSITY OF ARIZONA · PI FREGOSI, RALPH FRANK · 2012 to 2022
$3.5M
Functional and Structural Diversity in Hypoglossal MotoneuronsR01DC020889 · NIDCD · UNIVERSITY OF ARIZONA · PI Ralph Frank Fregosi · 2023 to 2026
$1.7M
NHLBI NIH HHS T32 HL007249NICHD NIH HHS R01 HD071302NIDCD NIH HHS R01 DC020889
6 · The paper itself

Abstract

Perinatal opioid exposure is a prevalent clinical concern linked to respiratory instability and adverse infant outcomes. The opioid buprenorphine is prescribed as a medication for opioid use disorder during pregnancy and used to treat neonatal opioid withdrawal syndrome, yet its direct effects on neonatal control of breathing have not been examined. Here, we asked how acute buprenorphine exposure affects breathing at rest, and during chemoreceptor stimulation. Using dual-chamber head-out plethysmography, we measured pulmonary ventilation rate (

Identifiers

PMID42182229
PMCPMC13192603

What OpenQuestion holds

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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.