ArticlebioRxiv : the preprint server for biology2026
Optogenetic circuit mapping reveals connectivity and synaptic physiology of T-stellate projections from the cochlear nucleus to the auditory midbrain.
Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
T-stellate neurons in the ventral cochlear nucleus (VCN) receive synaptic input from the cochlear nerve and encode information about sound frequency and intensity, including rapid fluctuations in sound intensity that are important for speech processing. T-stellate neurons are the only neuron class in the VCN that projects directly to the inferior colliculus (IC), the midbrain hub of auditory processing. However, which IC neuron populations receive T-stellate input and how T-stellate input influences IC neuron excitability remain unknown. Using channelrhodopsin-assisted circuit mapping and whole-cell patch clamp recordings in brain slices, we compared the synaptic strength, prevalence, and short-term synaptic plasticity of T-stellate input to two molecularly defined classes of IC neurons: GABAergic neuropeptide Y (NPY) neurons and glutamatergic vasoactive intestinal peptide (VIP) neurons. Our results revealed that T-stellate neurons provide excitatory input to both NPY and VIP neurons, with T-stellate input to NPY neurons having a higher incident rate, larger magnitude, and faster kinetics than T-stellate input to VIP neurons. In many instances, T-stellate input also recruited feedforward inhibition and feedforward excitation onto NPY and VIP neurons. In addition, T-stellate input to NPY and VIP neurons exhibited short-term synaptic depression that became larger in amplitude at higher stimulation frequencies. These data provide insights on how T-stellate neurons influence individual neuron types and local circuits in the IC, laying a mechanistic foundation for investigating how T-stellate input contributes to frequency tuning, amplitude modulation selectivity, and speech processing in the IC.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.