Evidence map›Paper›PMID 42182161›Full record

ArticlebioRxiv : the preprint server for biology2026

ppGpp regulates transcription elongation via direct and indirect inputs to RNA polymerase pausing and nucleotide addition.

Andreas U Mueller, Rachel A Mooney, Michael D Engstrom, Yu Bao, Michael B Wolfe, Balendra Sah, Jonathan Buscher, Jason Saba, James Liu, Seth A Darst and 1 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Andreas U MuellerLaboratory of Molecular Biophysics, The Rockefeller University, New York, NY 10065, USA.ORCID 0000-0003-3002-3695
Rachel A MooneyDepartment of Biochemistry, University of Wisconsin-Madison, Madison, WI 53706, USA.
Michael D EngstromDepartment of Biochemistry, University of Wisconsin-Madison, Madison, WI 53706, USA.
Yu BaoDepartment of Biochemistry, University of Wisconsin-Madison, Madison, WI 53706, USA.
Michael B WolfeDepartment of Biochemistry, University of Wisconsin-Madison, Madison, WI 53706, USA.
Balendra SahDepartment of Biochemistry, University of Wisconsin-Madison, Madison, WI 53706, USA.
Jonathan BuscherDepartment of Biochemistry, University of Wisconsin-Madison, Madison, WI 53706, USA.
Jason SabaDepartment of Biochemistry, University of Wisconsin-Madison, Madison, WI 53706, USA.
James LiuDepartment of Biochemistry, University of Wisconsin-Madison, Madison, WI 53706, USA.
Seth A DarstLaboratory of Molecular Biophysics, The Rockefeller University, New York, NY 10065, USA.
Robert LandickDepartment of Biochemistry, University of Wisconsin-Madison, Madison, WI 53706, USA.ORCID 0000-0002-5042-0383

Funding

NCCAT: National Center for CryoEM Access and Training- Supplement for Windows 10 and FFIU24GM129539 · NIGMS · NEW YORK STRUCTURAL BIOLOGY CENTER · PI DE MARCO, ALEX, KIEFT, JEFFREY S · 2018 to 2023
$53.9M
TRD #3: An automated and streamlined pipeline for in-situ molecular microscopyP41GM103310 · NIGMS · SCRIPPS RESEARCH INSTITUTE, THE · PI DE MARCO, ALEX, KIEFT, JEFFREY S · 2012 to 2021
$14.7M
STRUCTURE/FUNCTION OF TRANSCRIPTION COMPLEX RNA HAIRPINSR01GM038660 · NIGMS · WASHINGTON UNIVERSITY · PI Robert Landick · 1992 to 2026
$12.2M
Structure, function, and regulation of the bacterial transcription cycleR35GM118130 · NIGMS · ROCKEFELLER UNIVERSITY · PI DARST, SETH A. · 2016 to 2025
$8.9M
NIGMS NIH HHS P41 GM103310NIGMS NIH HHS R01 GM038660NIGMS NIH HHS R35 GM118130NIGMS NIH HHS U24 GM129539
6 · The paper itself

Abstract

The signaling molecules guanosine 5'-tri/diphosphate 3'-diphosphate, (p)ppGpp, control bacterial protein synthesis rates and cell growth by targeting transcription, translation, NTP synthesis, and other functions. In lineages like

Identifiers

PMID42182161
PMCPMC13192712

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.