ArticlebioRxiv : the preprint server for biology2026
Spatial distribution of blood-brain barrier membrane proteins is controlled by sorting motifs and physiological signals in vivo.
Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
The blood-brain barrier (BBB), formed by brain endothelial cells (BECs), creates a safe and homeostatic environment for proper brain function. Together with pericytes and astrocytes, the BBB controls substance influx and efflux into and out of the brain. While BECs are extraordinarily thin, their luminal and abluminal plasma membranes face markedly different environments: the blood and brain parenchyma, respectively. How BBB membrane proteins are spatially distributed between these membranes and the factors regulating their localization are not clear. Here, we establish a method for measuring polarized protein sorting at the BBB
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