Evidence map›Paper›PMID 42182109›Full record

ArticlebioRxiv : the preprint server for biology2026

Membrane-resolved epithelial electrophysiology revealed using extracellular electrochemical impedance spectroscopy (EEIS).

Athena J Chien, Erica Lull, Guiying Cui, Hanna Khor, Nael A McCarty, CraigR Forest

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Athena J ChienWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA 30332.ORCID 0000-0002-2814-9507
Erica LullG.W. Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, GA 30332.
Guiying CuiDepartment of Pediatrics, Emory University, Atlanta, GA.ORCID 0000-0002-7336-6076
Hanna KhorSchool of Electrical and Computer Engineering, Georgia Institute of Technology, Atlanta, GA 30332.
Nael A McCartyDepartment of Pediatrics, Emory University, Atlanta, GA.ORCID 0000-0002-4648-3912
CraigR ForestG.W. Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, GA 30332.ORCID 0000-0001-5343-1769

Funding

Novel Platforms for Systematic Optical Control of Complex Neural Circuits In VivoR01DA029639 · NIDA · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI BOYDEN, EDWARD S. · 2010 to 2023
$6.7M
High-throughput robotic analysis of integrated neuronal phenotypesR01EY023173 · NEI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI BOYDEN, EDWARD S., FOREST, CRAIG · 2012 to 2016
$4.3M
Automated cell-type-specific electrophysiology for understanding circuit dysregulation in Alzheimer's DiseaseRF1AG079269 · NIA · EMORY UNIVERSITY · PI FOREST, CRAIG, ROWAN, MATTHEW J.M. · 2022 to 2024
$2.4M
Scalable Cell- and Circuit-Targeted ElectrophysiologyR01NS102727 · NINDS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI BOYDEN, EDWARD S., FOREST, CRAIG · 2017 to 2020
$2.2M
In-vivo circuit activity measurement at single cell, sub-threshold resolutionU01MH106027 · NIMH · GEORGIA INSTITUTE OF TECHNOLOGY · PI FOREST, CRAIG, STANLEY, GARRETT B. · 2014 to 2016
$1.5M
NEI NIH HHS R01 EY023173NIA NIH HHS RF1 AG079269NIDA NIH HHS R01 DA029639NIMH NIH HHS U01 MH106027NINDS NIH HHS R01 NS102727
6 · The paper itself

Abstract

Conventional extracellular epithelial electrophysiology measurements report only bulk transepithelial resistance and capacitance, obscuring the distinct electrical properties of the apical and basolateral membranes. This limitation hinders research of epithelial diseases where dysfunction originates at a specific membrane domain-apical or basolateral-for example in cystic fibrosis or toxin-mediated airway injury. Here we present the extracellular electrochemical impedance spectroscopy (EEIS) technique that extracts membrane-specific electrophysiology by fitting impedance spectra to a two-resistor, two-capacitor (RCRC) model. Using human bronchiolar epithelial monolayers (16HBE), we show a correlation between the electrical time constants of the circuit (

Indexed as

apicalbasolateralElectrochemical impedance spectroscopyepitheliaextracellular electrophysiologyTEERtime constant

Identifiers

PMID42182109
PMCPMC13192661

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.