Evidence map›Paper›PMID 42182108›Full record

ArticlebioRxiv : the preprint server for biology2026

Epigenetic maintenance of PRC2-repressed chromatin requires RTT109 but not H3K56 acetylation.

Rochelle E Yap, Felicia Ebot-Ojong, Abigail J Ameri-Solanky, Zachary A Lewis

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Rochelle E YapDepartment of Microbiology, University of Georgia, Athens, GA 30602.ORCID 0000-0002-9181-280X
Felicia Ebot-OjongDepartment of Genetics, University of Georgia, Athens, GA 30602.ORCID 0000-0002-3408-3487
Abigail J Ameri-SolankyDepartment of Microbiology, University of Georgia, Athens, GA 30602.ORCID 0000-0001-5319-2630
Zachary A LewisDepartment of Microbiology, University of Georgia, Athens, GA 30602.ORCID 0000-0002-1735-8266

Funding

Control and function of repressive chromatin domainsR35GM152134 · NIGMS · UNIVERSITY OF GEORGIA · PI Zachary Lewis · 2024 to 2026
$1.1M
NIGMS NIH HHS R35 GM152134
6 · The paper itself

Abstract

In animals, plants, and some fungi, Polycomb Repressive Complex 2 (PRC2) catalyzes trimethylation of histone H3 lysine 27 (H3K27me3) to establish transcriptionally repressed chromatin. Here, we identify the histone acetyltransferase RTT109 as a key regulator of PRC2-repressed domains in the model fungus

Identifiers

PMID42182108
PMCPMC13192808

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.