ArticleFrontiers in microbiology2026
Antibiotic resistance in
Article in Frontiers in microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Authors and funding
6 authors.
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Abstract
Introduction: The aquatic environment is an ideal ecosystem for the development of antimicrobial resistance (AMR) as it can be impacted by many sources of antibiotic residues. Methods: To better understand the mechanism for AMR associated with exposure to subtherapeutic concentrations of antibiotics, we monitored the genetic and transcriptional changes in Results: Our results showed that all three independent lineages rapidly developed OTC resistance, starting after 3 days of exposure, with consistent adaptation patterns across replicates. Whole-genome sequencing identified recurrent point mutations, particularly in genes Discussion: These combined genetic and transcriptional changes likely drove the progressive development of resistance during incremental antibiotic exposure. Our findings support the notion that AMR can arise in aquatic bacteria through coordinated regulation of several intrinsic mechanisms and highlight potential risks during in-feed antibiotic usage in aquaculture.
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Registered trials
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