ArticleBiomaterial investigations in dentistry2026
Evaluation of an orthodontic adhesive containing 2 wt% nano-hydroxyapatite synthesized from a biogenic calcium precursor: antibacterial activity, calcium ion concentration, and enamel demineralization.
Article in Biomaterial investigations in dentistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: Enamel demineralization and white spot lesions remain common adverse effects during fixed orthodontic treatment, primarily due to plaque accumulation around brackets and the limited functionality of conventional orthodontic adhesives. This study aimed to evaluate the effect of incorporating 2 wt% nano-hydroxyapatite (nHAp), synthesized using a biogenic calcium precursor derived from Asian moon scallop ( Materials and Methods: nHAp powder was synthesized from scallop shell-derived calcium carbonate via calcination and precipitation methods and incorporated into a commercial orthodontic adhesive under controlled conditions. Antibacterial activity against Results: The nHAp-modified adhesive showed significantly greater antibacterial activity compared with the control group ( Conclusion: Within the limitations of this in vitro study, incorporation of 2 wt% nano-hydroxyapatite synthesized using a biogenic calcium precursor was associated with increased antibacterial activity, higher calcium ion concentration in the surrounding medium, and reduced enamel demineralization. Further studies are required to evaluate mechanical properties and clinical applicability.
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