Epithelioid hemangioendothelioma of the inferior vena cava: A case report.

Dillon Sommer, Kellie C Cho, Aditya Arora, Dong Ren, Ryan O'connell, Roozbeh Houshyar

Abstract readCase Reports

In one paragraph

Article in Radiology case reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

6 authors.

Dillon SommerIrvine Department of Radiological Sciences, University of California, 101 The City Drive South, Orange, CA 92868, USA.

Kellie C ChoIrvine Department of Radiological Sciences, University of California, 101 The City Drive South, Orange, CA 92868, USA.

Aditya AroraIrvine Department of Radiological Sciences, University of California, 101 The City Drive South, Orange, CA 92868, USA.

Dong RenIrvine Department of Pathology and Laboratory Medicine, University of California, 101 The City Drive South, Orange, CA 92868, USA.

Ryan O'connellIrvine Department of Pathology and Laboratory Medicine, University of California, 101 The City Drive South, Orange, CA 92868, USA.

Roozbeh HoushyarIrvine Department of Radiological Sciences, University of California, 101 The City Drive South, Orange, CA 92868, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Epithelioid hemangioendothelioma is a rare vascular neoplasm of endothelial origin with intermediate malignant potential and a highly variable clinical course. Although these lesions most commonly arise in the liver, lungs, bone, or soft tissues, primary involvement of large central veins is exceedingly rare and presents a diagnostic challenge on imaging. We report a case of a 65-year-old man with an incidentally detected enhancing intraluminal mass within the infrarenal inferior vena cava, retrospectively present for over 18 months. Initial endovascular biopsy was inconclusive, prompting surgical resection with inferior vena cava reconstruction. Final histopathology and molecular testing confirmed epithelioid hemangioendothelioma with a YAP1::TFE3 gene fusion. This case highlights the imaging appearance, differential diagnosis, pathologic correlation, and management considerations of intravascular epithelioid hemangioendothelioma and emphasizes the importance of longitudinal imaging review in evaluating indolent vascular lesions.

Indexed as

Case reportEpithelioid hemangioendotheliomaInferior vena cavaIntravascular neoplasmMagnetic resonance imaging

Identifiers

PMID42181953

DOI10.1016/j.radcr.2026.04.047

PMCPMC13191612

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