Evidence map›Paper›PMID 42181910›Full record

ArticleJBMR plus2026

Design and validation of a perfusion bioreactor for long-term human bone explant culture.

Mahsa Zojaji, Annelise G Pageau, Teodora Maluckov, Johannes Eichwalder, Mariya Peskova, Corey Smith, George S Athwal, Maud Gorbet, Louis M Ferreira, Nikolas Knowles

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JBMR plus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Mahsa ZojajiDepartment of Kinesiology and Health Sciences, University of Waterloo, Waterloo, ON N2L 3G1, Canada.ORCID https://orcid.org/0000-0003-1500-8278
Annelise G PageauDepartment of Kinesiology and Health Sciences, University of Waterloo, Waterloo, ON N2L 3G1, Canada.
Teodora MaluckovDepartment of Kinesiology and Health Sciences, University of Waterloo, Waterloo, ON N2L 3G1, Canada.
Johannes EichwalderDepartment of Kinesiology and Health Sciences, University of Waterloo, Waterloo, ON N2L 3G1, Canada.
Mariya PeskovaDepartment of Systems Design Engineering, University of Waterloo, Waterloo, ON N2L 3G1, Canada.
Corey SmithRoth|McFarlane Hand and Upper Limb Centre, London, ON N6A 4V2,  Canada.
George S AthwalRoth|McFarlane Hand and Upper Limb Centre, London, ON N6A 4V2,  Canada.
Maud GorbetDepartment of Systems Design Engineering, University of Waterloo, Waterloo, ON N2L 3G1, Canada.
Louis M FerreiraRoth|McFarlane Hand and Upper Limb Centre, London, ON N6A 4V2,  Canada.
Nikolas KnowlesDepartment of Kinesiology and Health Sciences, University of Waterloo, Waterloo, ON N2L 3G1, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ex vivo bone cultures offer a unique platform to study mechanobiology by preserving bone cells and marrow within their native extracellular matrix. We present a 3D-printable modified ZetOS bioreactor for long-term ex vivo culture of human osteoarthritic trabecular bone. Computational fluid dynamics simulations guided design optimization and supported improved average flow velocity and shear stress throughout the central region of the bone construct in the modified bioreactor design. Humeral head osteotomies from four osteoarthritic patients (age: 65-77 yr, 1 female, 3 males) were prepared within 2 h of surgery. Trabecular bone cores ([Formula: see text]9.15 ± 0.14 [Formula: see text] 9.5 ± 2.0 mm) were cultured under static conditions (

Indexed as

bone remodelingcomputational fluid dynamicsex vivo bone cultureosteoarthritisperfusion bioreactor

Identifiers

PMID42181910
PMCPMC13192549

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.