Evidence map›Paper›PMID 42181889›Full record

ArticleFrontiers in pharmacology2026

Metabolites extracted from browntop millet (Urochloa ramosa (L.) T.Q. Nguyen) mitigated the proliferation of breast- and colorectal carcinoma cells

Mahadevaswamy G Kuruburu, Venugopal R Bovilla, Rimshia Naaz, Zonunsiami Leihang, Sahana Shivaramakrishna, P Pramod Kumar, K V Harish Prashanth, Tousif Ahmed Hediyal, Dugganaboyana Guru Kumar, Saravana Babu Chidambaram and 5 more

Abstract read
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Article in Frontiers in pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Mahadevaswamy G KuruburuCenter of Excellence in Molecular Biology and Regenerative Medicine (A DST-FIST Supported Center), Department of Biochemistry (A DST-FIST Supported Department), JSS Medical College, JSS Academy of Higher Education & Research (JSS AHER), Mysuru, Karnataka, India.
Venugopal R BovillaCenter of Excellence in Molecular Biology and Regenerative Medicine (A DST-FIST Supported Center), Department of Biochemistry (A DST-FIST Supported Department), JSS Medical College, JSS Academy of Higher Education & Research (JSS AHER), Mysuru, Karnataka, India.
Rimshia NaazCenter of Excellence in Molecular Biology and Regenerative Medicine (A DST-FIST Supported Center), Department of Biochemistry (A DST-FIST Supported Department), JSS Medical College, JSS Academy of Higher Education & Research (JSS AHER), Mysuru, Karnataka, India.
Zonunsiami LeihangCenter of Excellence in Molecular Biology and Regenerative Medicine (A DST-FIST Supported Center), Department of Biochemistry (A DST-FIST Supported Department), JSS Medical College, JSS Academy of Higher Education & Research (JSS AHER), Mysuru, Karnataka, India.
Sahana ShivaramakrishnaDepartment of Biochemistry, School of Life Science, JSS Academy of Higher Education & Research (JSS AHER), Mysuru, Karnataka, India.
P Pramod KumarDepartment of Biochemistry, CSIR-Central Food Technological Research Institute, Mysore, Karnataka, India.
K V Harish PrashanthDepartment of Biochemistry, CSIR-Central Food Technological Research Institute, Mysore, Karnataka, India.
Tousif Ahmed HediyalDepartment of Pharmacology, JSS College of Pharmacy, JSS Academy of Higher Education & Research, Mysuru, Karnataka, India.
Dugganaboyana Guru KumarDepartment of Biochemistry, School of Life Science, JSS Academy of Higher Education & Research (JSS AHER), Mysuru, Karnataka, India.
Saravana Babu ChidambaramDepartment of Pharmacology, JSS College of Pharmacy, JSS Academy of Higher Education & Research, Mysuru, Karnataka, India.
T Durai Ananda KumarDepartment of Pharmaceutical Chemistry, JSS College of Pharmacy, Ooty, Tamil Nadu, India.
Danielle TwilleyDepartment of Plant and Soil Sciences, Faculty of Natural and Agricultural sciences, University of Pretoria, Pretoria, South Africa.
Namrita LallDepartment of Plant and Soil Sciences, Faculty of Natural and Agricultural sciences, University of Pretoria, Pretoria, South Africa.
Preethi G AnantharajuCenter of Excellence in Molecular Biology and Regenerative Medicine (A DST-FIST Supported Center), Department of Biochemistry (A DST-FIST Supported Department), JSS Medical College, JSS Academy of Higher Education & Research (JSS AHER), Mysuru, Karnataka, India.
SubbaRao V MadhunapantulaCenter of Excellence in Molecular Biology and Regenerative Medicine (A DST-FIST Supported Center), Department of Biochemistry (A DST-FIST Supported Department), JSS Medical College, JSS Academy of Higher Education & Research (JSS AHER), Mysuru, Karnataka, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Epidemiological studies have demonstrated an inverse correlation between millet-based diets and incidence of cancers of colon and rectum. These findings highlight the potential of millets as functional foods for effective management of cancers. But the experimental evidences supporting these observations remain limited. Among diverse millet varieties, Browntop millet (BTM) has recently been reported to possess potent anti-oxidant and DNA protection properties. Therefore, in the current study we have hypothesized that metabolite rich fractions of browntop millet, particularly the free metabolites extract (BTM-F), exert anticancer effects by targeting key oncogenic pathways that regulate cell proliferation, cell cycle progression, and apoptosis in breast and colorectal cancers. To test this hypothesis, the study aimed to (a) chemically characterize free and bound metabolites (BTM-F and BTM-B) using UPLC-QTOF-MS; (b) evaluate their anticancer efficacy

Indexed as

breast cancerbrowntop milletcolon cancerEACphenolics extract

Identifiers

PMID42181889
PMCPMC13190552

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.