Evidence map›Paper›PMID 42181883›Full record

ArticleFrontiers in pharmacology2026

Investigating therapeutic response to netarsudil in glaucoma subjects with the

Anusha Mamidipaka, Isabel Di Rosa, Marine-Ayan Ibrahim Aibo, Fangming Jin, Rebecca Salowe, Roy Lee, Mina Halimitabrizi, Leila Ghaffari, Victoria Addis, Laxmi Moksha and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Anusha MamidipakaDepartment of Ophthalmology, Center for Genetics of Complex Disease, Scheie Eye Institute, University of Pennsylvania, Philadelphia, PA, United States.
Isabel Di RosaDepartment of Ophthalmology, Center for Genetics of Complex Disease, Scheie Eye Institute, University of Pennsylvania, Philadelphia, PA, United States.
Marine-Ayan Ibrahim AiboDepartment of Ophthalmology, Center for Genetics of Complex Disease, Scheie Eye Institute, University of Pennsylvania, Philadelphia, PA, United States.
Fangming JinCenter for Preventive Ophthalmology and Biostatistics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, United States.
Rebecca SaloweDepartment of Ophthalmology, Center for Genetics of Complex Disease, Scheie Eye Institute, University of Pennsylvania, Philadelphia, PA, United States.
Roy LeeDepartment of Ophthalmology, Center for Genetics of Complex Disease, Scheie Eye Institute, University of Pennsylvania, Philadelphia, PA, United States.
Mina HalimitabriziDepartment of Ophthalmology, Center for Genetics of Complex Disease, Scheie Eye Institute, University of Pennsylvania, Philadelphia, PA, United States.
Leila GhaffariDepartment of Ophthalmology, Center for Genetics of Complex Disease, Scheie Eye Institute, University of Pennsylvania, Philadelphia, PA, United States.
Victoria AddisDepartment of Ophthalmology, Center for Genetics of Complex Disease, Scheie Eye Institute, University of Pennsylvania, Philadelphia, PA, United States.
Laxmi MokshaDepartment of Ophthalmology, Center for Genetics of Complex Disease, Scheie Eye Institute, University of Pennsylvania, Philadelphia, PA, United States.
Gui-Shuang YingCenter for Preventive Ophthalmology and Biostatistics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, United States.
Joan M O'BrienDepartment of Ophthalmology, Center for Genetics of Complex Disease, Scheie Eye Institute, University of Pennsylvania, Philadelphia, PA, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Methods: We analyzed 1,844 African ancestry subjects with POAG, comparing baseline demographic and ocular phenotypes across Results: Baseline glaucoma severity and ocular phenotypes including IOP were similar across all Discussion: Despite a strong biological rationale linking

Indexed as

ARHGEF12netarsudilneuroprotectionprimary open-angle glaucomaRho kinase (ROCK) inhibitorRhopressaRho/ROCK pathway

Identifiers

PMID42181883
PMCPMC13194400

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.